Literature DB >> 11512519

Aminoglycoside-modifying enzymes: mechanisms of catalytic processes and inhibition.

E Azucena1, S Mobashery.   

Abstract

The most prevalent mechanism for resistance to aminoglycoside antibiotics is mediated through their enzymatic modification in resistant organisms. Dozens of aminoglycoside-modifying enzymes are known at the gene sequence level, but few have been characterized in the details of their mechanism. This review summarizes the state of knowledge of the best studied of these enzymes, focusing on their catalytic mechanisms and inhibition.

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Year:  2001        PMID： 11512519     DOI： 10.1054/drup.2001.0197

Source DB:  PubMed          Journal:  Drug Resist Updat        ISSN： 1368-7646            Impact factor:   18.500


  27 in total

1.  Nucleotide sequence and evolution of the five-plasmid complement of the phytopathogen Pseudomonas syringae pv. maculicola ES4326.

Authors:  John Stavrinides; David S Guttman
Journal:  J Bacteriol       Date:  2004-08       Impact factor: 3.490

Review 2.  Aminoglycoside resistance in Pseudomonas aeruginosa.

Authors:  Keith Poole
Journal:  Antimicrob Agents Chemother       Date:  2005-02       Impact factor: 5.191

3.  Crystallization and preliminary crystallographic analysis of an aminoglycoside kinase from Legionella pneumophila.

Authors:  Christopher T Lemke; Jiyoung Hwang; Bing Xiong; Nicholas P Cianciotto; Albert M Berghuis
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2005-06-01

4.  IBR3, a novel peroxisomal acyl-CoA dehydrogenase-like protein required for indole-3-butyric acid response.

Authors:  Bethany K Zolman; Michelle Nyberg; Bonnie Bartel
Journal:  Plant Mol Biol       Date:  2007-02-03       Impact factor: 4.076

5.  Synthesis and use of sulfonamide-, sulfoxide-, or sulfone-containing aminoglycoside-CoA bisubstrates as mechanistic probes for aminoglycoside N-6'-acetyltransferase.

Authors:  Feng Gao; Xuxu Yan; Omar Zahr; Aaron Larsen; Kenward Vong; Karine Auclair
Journal:  Bioorg Med Chem Lett       Date:  2008-09-06       Impact factor: 2.823

6.  Synthesis of 4'-aminopantetheine and derivatives to probe aminoglycoside N-6'-acetyltransferase.

Authors:  Xuxu Yan; T Olukayode Akinnusi; Aaron T Larsen; Karine Auclair
Journal:  Org Biomol Chem       Date:  2011-01-12       Impact factor: 3.876

7.  Structural analysis of a putative aminoglycoside N-acetyltransferase from Bacillus anthracis.

Authors:  Maria M Klimecka; Maksymilian Chruszcz; Jose Font; Tatiana Skarina; Igor Shumilin; Olena Onopryienko; Przemyslaw J Porebski; Marcin Cymborowski; Matthew D Zimmerman; Jeremy Hasseman; Ian J Glomski; Lukasz Lebioda; Alexei Savchenko; Aled Edwards; Wladek Minor
Journal:  J Mol Biol       Date:  2011-05-13       Impact factor: 5.469

8.  The gene cluster for spectinomycin biosynthesis and the aminoglycoside-resistance function of spcM in Streptomyces spectabilis.

Authors:  Kyoung-Rok Kim; Tae-Jong Kim; Joo-Won Suh
Journal:  Curr Microbiol       Date:  2008-07-29       Impact factor: 2.188

9.  Staphylococcus aureus extracellular vesicles carry biologically active β-lactamase.

Authors:  Jaewook Lee; Eun-Young Lee; Si-Hyun Kim; Dae-Kyum Kim; Kyong-Su Park; Kwang Pyo Kim; Yoon-Keun Kim; Tae-Young Roh; Yong Song Gho
Journal:  Antimicrob Agents Chemother       Date:  2013-03-25       Impact factor: 5.191

10.  Identification of an Inhibitor of the Aminoglycoside 6'-N-Acetyltransferase type Ib [AAC(6')-Ib] by Glide Molecular Docking.

Authors:  Kevin Chiem; Saumya Jani; Brooke Fuentes; David L Lin; Madeline E Rasche; Marcelo E Tolmasky
Journal:  Medchemcomm       Date:  2015-11-03       Impact factor: 3.597
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