BACKGROUND: The magnitude of the association between Helicobacter pylori and incidence of gastric cancer is unclear. H pylori infection and the circulating antibody response can be lost with development of cancer; thus retrospective studies are subject to bias resulting from classification of cases as H pylori negative when they were infected in the past. AIMS: To combine data from all case control studies nested within prospective cohorts to assess more reliably the relative risk of gastric cancer associated with H pylori infection. To investigate variation in relative risk by age, sex, cancer type and subsite, and interval between blood sampling and cancer diagnosis. METHODS: Studies were eligible if blood samples for H pylori serology were collected before diagnosis of gastric cancer in cases. Identified published studies and two unpublished studies were included. Individual subject data were obtained for each. Matched odds ratios (ORs) and 95% confidence intervals (95% CI) were calculated for the association between H pylori and gastric cancer. RESULTS: Twelve studies with 1228 gastric cancer cases were considered. The association with H pylori was restricted to non-cardia cancers (OR 3.0; 95% CI 2.3-3.8) and was stronger when blood samples for H pylori serology were collected 10+ years before cancer diagnosis (5.9; 3.4-10.3). H pylori infection was not associated with an altered overall risk of cardia cancer (1.0; 0.7-1.4). CONCLUSIONS: These results suggest that 5.9 is the best estimate of the relative risk of non-cardia cancer associated with H pylori infection and that H pylori does not increase the risk of cardia cancer. They also support the idea that when H pylori status is assessed close to cancer diagnosis, the magnitude of the non-cardia association may be underestimated.
BACKGROUND: The magnitude of the association between Helicobacter pylori and incidence of gastric cancer is unclear. H pylori infection and the circulating antibody response can be lost with development of cancer; thus retrospective studies are subject to bias resulting from classification of cases as H pylori negative when they were infected in the past. AIMS: To combine data from all case control studies nested within prospective cohorts to assess more reliably the relative risk of gastric cancer associated with H pylori infection. To investigate variation in relative risk by age, sex, cancer type and subsite, and interval between blood sampling and cancer diagnosis. METHODS: Studies were eligible if blood samples for H pylori serology were collected before diagnosis of gastric cancer in cases. Identified published studies and two unpublished studies were included. Individual subject data were obtained for each. Matched odds ratios (ORs) and 95% confidence intervals (95% CI) were calculated for the association between H pylori and gastric cancer. RESULTS: Twelve studies with 1228 gastric cancer cases were considered. The association with H pylori was restricted to non-cardia cancers (OR 3.0; 95% CI 2.3-3.8) and was stronger when blood samples for H pylori serology were collected 10+ years before cancer diagnosis (5.9; 3.4-10.3). H pylori infection was not associated with an altered overall risk of cardia cancer (1.0; 0.7-1.4). CONCLUSIONS: These results suggest that 5.9 is the best estimate of the relative risk of non-cardia cancer associated with H pylori infection and that H pylori does not increase the risk of cardia cancer. They also support the idea that when H pylori status is assessed close to cancer diagnosis, the magnitude of the non-cardia association may be underestimated.
Authors: W H Chow; M J Blaser; W J Blot; M D Gammon; T L Vaughan; H A Risch; G I Perez-Perez; J B Schoenberg; J L Stanford; H Rotterdam; A B West; J F Fraumeni Journal: Cancer Res Date: 1998-02-15 Impact factor: 12.701
Authors: H Yamagata; Y Kiyohara; K Aoyagi; I Kato; H Iwamoto; K Nakayama; H Shimizu; Y Tanizaki; H Arima; N Shinohara; H Kondo; T Matsumoto; M Fujishima Journal: Arch Intern Med Date: 2000-07-10
Authors: Sureyya Ozcan; Donald A Barkauskas; L Renee Ruhaak; Javier Torres; Cara L Cooke; Hyun Joo An; Serenus Hua; Cynthia C Williams; Lauren M Dimapasoc; Jae Han Kim; Margarita Camorlinga-Ponce; David Rocke; Carlito B Lebrilla; Jay V Solnick Journal: Cancer Prev Res (Phila) Date: 2013-12-10
Authors: Ramin Shakeri; Reza Malekzadeh; Dariush Nasrollahzadeh; Michael Pawlita; Michael Pawilta; Gwen Murphy; Farhad Islami; Masoud Sotoudeh; Angelika Michel; Arash Etemadi; Tim Waterboer; Hossein Poustchi; Paul Brennan; Paolo Boffetta; Sanford M Dawsey; Farin Kamangar; Christian C Abnet Journal: Cancer Res Date: 2015-09-17 Impact factor: 12.701
Authors: Arto Kokkola; Johanna Louhimo; Pauli Puolakkainen; Henrik Alfthan; Caj Haglund; Hilpi Rautelin Journal: World J Gastroenterol Date: 2005-02-21 Impact factor: 5.742
Authors: Eugenia H Miranti; Rachael Stolzenberg-Solomon; Stephanie J Weinstein; Jacob Selhub; Satu Männistö; Philip R Taylor; Neal D Freedman; Demetrius Albanes; Christian C Abnet; Gwen Murphy Journal: Int J Cancer Date: 2017-06-21 Impact factor: 7.396