Literature DB >> 11511387

Influence of anesthesia on brain distribution of [(11)C]methamphetamine in monkeys in positron emission tomography (PET) study.

M Mizugaki1, N Nakagawa, H Nakamura, T Hishinuma, Y Tomioka, S Ishiwata, T Ido, R Iwata, Y Funaki, M Itoh, M Higuchi, N Okamura, T Fujiwara, M Sato, K Shindo, S Yoshida.   

Abstract

We investigated the influence of anesthesia on the brain distribution of [11C]methamphetamine (MAP) obtained by the positron emission tomography (PET) using the normal rhesus monkeys. We clarified that the brain uptake of [11C]MAP under halothane anesthesia was faster and higher than that under pentobarbital. The difference of the effect of anesthesia is an important problem in pharmacokinetic study in PET with experimental animals.

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Year:  2001        PMID： 11511387     DOI： 10.1016/s0006-8993(01)02669-5

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  4 in total

1.  Synthesis, fluorine-18 radiolabeling, and biological evaluation of N-((E)-4-fluorobut-2-en-1-yl)-2beta-carbomethoxy-3beta-(4'-halophenyl)nortropanes: candidate radioligands for in vivo imaging of the brain dopamine transporter with positron emission tomography.

Authors:  Jeffrey S Stehouwer; Lauryn M Daniel; Ping Chen; Ronald J Voll; Larry Williams; Susan J Plott; John R Votaw; Michael J Owens; Leonard Howell; Mark M Goodman
Journal:  J Med Chem       Date:  2010-08-12       Impact factor: 7.446

2.  Fluorine-18 Radiolabeled PET Tracers for Imaging Monoamine Transporters: Dopamine, Serotonin, and Norepinephrine.

Authors:  Jeffrey S Stehouwer; Mark M Goodman
Journal:  PET Clin       Date:  2009-01

3.  PET studies of d-methamphetamine pharmacokinetics in primates: comparison with l-methamphetamine and ( --)-cocaine.

Authors:  Joanna S Fowler; Carsten Kroll; Richard Ferrieri; David Alexoff; Jean Logan; Stephen L Dewey; Wynne Schiffer; David Schlyer; Pauline Carter; Payton King; Colleen Shea; Youwen Xu; Lisa Muench; Helene Benveniste; Paul Vaska; Nora D Volkow
Journal:  J Nucl Med       Date:  2007-09-14       Impact factor: 10.057

Review 4.  Mapping brain function in freely moving subjects.

Authors:  Daniel P Holschneider; Jean-Michel I Maarek
Journal:  Neurosci Biobehav Rev       Date:  2004-09       Impact factor: 8.989
  4 in total

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