Literature DB >> 1151117

Dichotomy in response to indomethacin in UV-C and UV-B induced ultraviolet light inflammation.

W H Eaglstein, A R Marsico.   

Abstract

In subjects irradiated with both UV-C and UV-B ultraviolet light (UVL), 10 mug of intradermal indomethacin decreased the redness in all 13 of the UV-B irradiated areas but in only 2 of 13 of the UV-C irradiated areas. Higher doses of intradermal indomethacin (50 mug and 100 mug) decreased the redness produced by UV-C irradiation in 6 subjects. It is suggested that the failure of 10 mug of indomethacin to decrease the redness of the UV-C induced inflammation, while decreasing the redness in the UV-B induced inflammation, is consistent with the possibility that prostaglandins participate in UV-B but not UV-C induced inflammation.

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Year:  1975        PMID: 1151117     DOI: 10.1111/1523-1747.ep12598255

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN: 0022-202X            Impact factor:   8.551


  6 in total

1.  The effect of short wavelength ultraviolet (C (254 nm), irradiation on arachidonic acid and prostaglandins E2 and F2alpha concentrations in human skin [proceedings].

Authors:  M W Greaves; C N Hensby; N A Plummer; A P Warin
Journal:  Br J Pharmacol       Date:  1977-11       Impact factor: 8.739

2.  Increased prostaglandins E2 and F2alpha in human skin at 6 and 24 h after ultraviolet B irradiation (290- 320 nm).

Authors:  A K Black; M W Greaves; C N Hensby; N A Plummer
Journal:  Br J Clin Pharmacol       Date:  1978-05       Impact factor: 4.335

3.  [Photoaugmentation. a photobiological phenomenon (author's transl)].

Authors:  H Spiegel; G Plewig; C Hofmann; O Braun-Falco
Journal:  Arch Dermatol Res       Date:  1978-04-07       Impact factor: 3.017

4.  Effect of dietary omega-3 and omega-6 fatty acid sources on PUVA-induced cutaneous toxicity and tumorigenesis in the hairless mouse.

Authors:  A Yen; H S Black; J Tschen
Journal:  Arch Dermatol Res       Date:  1994       Impact factor: 3.017

5.  Irradiation of human skin by short wavelength ultraviolet radiation (100--290 nm) (u.v.C): increased concentrations of arachidonic acid and prostaglandines E2 and F2alpha.

Authors:  R D Camp; M W Greaves; C N Hensby; N A Plummer; A P Warin
Journal:  Br J Clin Pharmacol       Date:  1978-08       Impact factor: 4.335

6.  The effects of indomethacin on arachidonic acid and prostaglandins e2 and f2alpha levels in human skin 24 h after u.v.B and u.v.C irradiation.

Authors:  A K Black; M W Greaves; C N Hensby; N A Plummer; A P Warin
Journal:  Br J Clin Pharmacol       Date:  1978-09       Impact factor: 4.335

  6 in total

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