| Literature DB >> 11509981 |
V M Dirsch, H Stuppner, A M Vollmar.
Abstract
Cytotoxicity is a well characterized property of sesquiterpene lactones. In the present study, the question was addressed whether sesquiterpene lactones mediate their cytotoxic effect by triggering apoptosis. Four compounds, ambrosin, alantolactone, hymenin and helenalin were shown to induce apoptosis in Jurkat leukemia T cells as judged by cell morphology, the appearance of apoptotic nuclei as well as the translocation of phosphatidylserine to the outer surface of the cell membrane.Entities:
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Year: 2001 PMID： 11509981 DOI： 10.1055/s-2001-16478
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352