Literature DB >> 11509734

Immunocyte Ca2+ influx system mediated by LTRPC2.

Y Sano1, K Inamura, A Miyake, S Mochizuki, H Yokoi, H Matsushime, K Furuichi.   

Abstract

We characterized an activation mechanism of the human LTRPC2 protein, a member of the transient receptor potential family of ion channels, and demonstrated that LTRPC2 mediates Ca2+ influx into immunocytes. Intracellular pyrimidine nucleotides, adenosine 5'-diphosphoribose (ADPR), and nicotinamide adenine dinucleotide (NAD), directly activated LTRPC2, which functioned as a Ca2+-permeable nonselective cation channel and enabled Ca2+ influx into cells. This activation was suppressed by intracellular adenosine triphosphate. These results reveal that ADPR and NAD act as intracellular messengers and may have an important role in Ca2+ influx by activating LTRPC2 in immunocytes.

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Year:  2001        PMID： 11509734     DOI： 10.1126/science.1062473

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  187 in total

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Review 3.  NAD+ surfaces again.

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Review 5.  International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family.

Authors:  Long-Jun Wu; Tara-Beth Sweet; David E Clapham
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6.  Permeating proton found guilty in compromising TRPM2 channel activity.

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8.  Activation of store-operated I(CRAC) by hydrogen peroxide.

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9.  Transient receptor potential melastatin 2 governs stress-induced depressive-like behaviors.

Authors:  Seung Yeon Ko; Sung Eun Wang; Han Kyu Lee; Sungsin Jo; Jinil Han; Seung Hoon Lee; Miyeon Choi; Hye-Ryeong Jo; Jee Young Seo; Sung Jun Jung; Hyeon Son
Journal:  Proc Natl Acad Sci U S A       Date:  2019-01-14       Impact factor: 11.205

10.  Depletion of the Human Ion Channel TRPM2 in Neuroblastoma Demonstrates Its Key Role in Cell Survival through Modulation of Mitochondrial Reactive Oxygen Species and Bioenergetics.

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Journal:  J Biol Chem       Date:  2016-09-30       Impact factor: 5.157
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