Literature DB >> 11508693

Decreased susceptibility of heart mitochondria from diabetic GK rats to mitochondrial permeability transition induced by calcium phosphate.

P J Oliveira1, A P Rolo, R Seiça, C M Palmeira, M S Santos, A J Moreno.   

Abstract

Type 2 diabetes (or non-insulin dependent diabetes mellitus, NIDDM) is a common metabolic disease in man. The Goto-Kakizaki (GK) rat has been designed as a NIDDM model. Previous studies with this strain have shown differences at the mitochondrial level. The mitochondrial permeability transition (MPT) is a widely studied phenomenon but yet poorly understood, that leads to mitochondrial dysfunction and cell death. The aim of this work was to compare the differences in susceptibility of induction of the MPT with calcium phosphate in GK and Wistar rats. Our results show that heart mitochondria from GK rats are less susceptible to the induction of MPT, and show a larger calcium accumulation before the overall loss of mitochondrial impermeability.

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Year:  2001        PMID： 11508693     DOI： 10.1023/a:1010482017540

Source DB:  PubMed          Journal:  Biosci Rep        ISSN： 0144-8463            Impact factor:   3.840


  10 in total

1.  Role of NAD(P)H oxidase in superoxide generation and endothelial dysfunction in Goto-Kakizaki (GK) rats as a model of nonobese NIDDM.

Authors:  Sachin Gupte; Nazar Labinskyy; Rakhee Gupte; Anna Csiszar; Zoltan Ungvari; John G Edwards
Journal:  PLoS One       Date:  2010-07-26       Impact factor: 3.240

2.  Chromium supplementation improves glucose tolerance in diabetic Goto-Kakizaki rats.

Authors:  Aicha Abdourahman; John G Edwards
Journal:  IUBMB Life       Date:  2008-08       Impact factor: 3.885

Review 3.  Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities.

Authors:  William I Sivitz; Mark A Yorek
Journal:  Antioxid Redox Signal       Date:  2010-04       Impact factor: 8.401

4.  Cardioprotection in the aging, diabetic heart: the loss of protective Akt signalling.

Authors:  Hannah J Whittington; Idris Harding; Clemency I M Stephenson; Robert Bell; Derek J Hausenloy; Mihaela M Mocanu; Derek M Yellon
Journal:  Cardiovasc Res       Date:  2013-05-30       Impact factor: 10.787

Review 5.  Beneficial effects of exercise on muscle mitochondrial function in diabetes mellitus.

Authors:  José A Lumini; José Magalhães; Paulo J Oliveira; António Ascensão
Journal:  Sports Med       Date:  2008       Impact factor: 11.136

6.  Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy.

Authors:  Angela V Hafner; Jing Dai; Ana P Gomes; Chun-Yang Xiao; Carlos M Palmeira; Anthony Rosenzweig; David A Sinclair
Journal:  Aging (Albany NY)       Date:  2010-12       Impact factor: 5.682

7.  The diabetic heart: too sweet for its own good?

Authors:  Hannah J Whittington; Girish G Babu; Mihaela M Mocanu; Derek M Yellon; Derek J Hausenloy
Journal:  Cardiol Res Pract       Date:  2012-02-22       Impact factor: 1.866

8.  Effects of hypoglycemia on myocardial susceptibility to ischemia-reperfusion injury and preconditioning in hearts from rats with and without type 2 diabetes.

Authors:  Kim B Pælestik; Nichlas R Jespersen; Rebekka V Jensen; Jacob Johnsen; Hans Erik Bøtker; Steen B Kristiansen
Journal:  Cardiovasc Diabetol       Date:  2017-11-09       Impact factor: 9.951

9.  Nitric oxide protects the heart from ischemia-induced apoptosis and mitochondrial damage via protein kinase G mediated blockage of permeability transition and cytochrome c release.

Authors:  Vilmante Borutaite; Ramune Morkuniene; Odeta Arandarcikaite; Aiste Jekabsone; Jurgita Barauskaite; Guy C Brown
Journal:  J Biomed Sci       Date:  2009-08-11       Impact factor: 8.410

10.  Differential Mitochondrial Adaptation in Primary Vascular Smooth Muscle Cells from a Diabetic Rat Model.

Authors:  Amy C Keller; Leslie A Knaub; P Mason McClatchey; Chelsea A Connon; Ron Bouchard; Matthew W Miller; Kate E Geary; Lori A Walker; Dwight J Klemm; Jane E B Reusch
Journal:  Oxid Med Cell Longev       Date:  2016-01-11       Impact factor: 6.543
  10 in total

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