Literature DB >> 11508662

P8 expression is induced in acinar cells during chronic pancreatitis.

Y Motoo1, J L Iovanna, G V Mallo, S B Su, M J Xie, N Sawabu.   

Abstract

The p8 gene is barely expressed in the normal pancreas, but is overexpressed in acute pancreatitis. To elucidate the dynamic expression of p8 mRNA and its significance in the course of chronic pancreatitis, we investigated the p8 expression in spontaneous chronic pancreatitis in the WBN/Kob rat as well as in humans and arginine-treated rat pancreatic acinar AR4-2J cells. p8 mRNA was significantly increased at 12 weeks when chronic pancreatitis first appeared in the WBN/Kob rats. p8 was immunolocalized in the acinar cell nuclei. Acinar cell apoptosis was significantly increased at 12 and 20 weeks in the WBN/Kob rats. In AR4-2J cells, p8 mRNA was significantly induced at 4 hr after arginine addition. Apoptosis of AR4-2J cells was not increased during the strong expression of p8 mRNA. These results suggest that p8 is induced in the acinar cells during chronic pancreatitis as the self-defence mechanism against proapoptotic insults.

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Year:  2001        PMID： 11508662     DOI： 10.1023/a:1010637100933

Source DB:  PubMed          Journal:  Dig Dis Sci        ISSN： 0163-2116            Impact factor:   3.199


  16 in total

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Authors:  S Vasseur; G Vidal Mallo; F Fiedler; H Bödeker; E Cánepa; S Moreno; J L Iovanna
Journal:  Eur J Biochem       Date:  1999-02

2.  Arginine induces apoptosis and gene expression of pancreatitis-associated protein (PAP) in rat pancreatic acinar AR4-2J cells.

Authors:  Y Motoo; K Taga; S B Su; M J Xie; N Sawabu
Journal:  Pancreas       Date:  2000-01       Impact factor: 3.327

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Authors:  S B Su; Y Motoo; M J Xie; J Sakai; H Taga; N Sawabu
Journal:  Pancreas       Date:  1999-10       Impact factor: 3.327

4.  Cloning and expression of the rat p8 cDNA, a new gene activated in pancreas during the acute phase of pancreatitis, pancreatic development, and regeneration, and which promotes cellular growth.

Authors:  G V Mallo; F Fiedler; E L Calvo; E M Ortiz; S Vasseur; V Keim; J Morisset; J L Iovanna
Journal:  J Biol Chem       Date:  1997-12-19       Impact factor: 5.157

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Authors:  Y F Jiang; M I Vaccaro; F Fiedler; E L Calvo; J L Iovanna
Journal:  Biochem Biophys Res Commun       Date:  1999-07-14       Impact factor: 3.575

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Authors:  J L Iovanna; V Keim; R Michel; J C Dagorn
Journal:  Am J Physiol       Date:  1991-09

7.  The pancreatitis-associated protein is induced by free radicals in AR4-2J cells and confers cell resistance to apoptosis.

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Authors:  M J Xie; Y Motoo; S B Su; N Sawabu
Journal:  Pancreas       Date:  2001-05       Impact factor: 3.327

Review 9.  The acute phase reaction of the exocrine pancreas. Gene expression and synthesis of pancreatitis-associated proteins.

Authors:  V Keim; J L Iovanna; J C Dagorn
Journal:  Digestion       Date:  1994       Impact factor: 3.216

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Journal:  Int J Pancreatol       Date:  1993-02
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Journal:  Endocrine       Date:  2010-11-11       Impact factor: 3.633

3.  Effect of carboxamide derivative IS-741 on rat spontaneous chronic pancreatitis.

Authors:  Min-Jue Xie; Yoshiharu Motoo; Shi-Bing Su; Juan Lucio Iovanna; Norio Sawabu
Journal:  Dig Dis Sci       Date:  2002-01       Impact factor: 3.199

4.  Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation.

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5.  Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis.

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Review 6.  Targeting Fibrosis: The Bridge That Connects Pancreatitis and Pancreatic Cancer.

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  6 in total

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