| Literature DB >> 11507230 |
F A Koning1, D Schols, H Schuitemaker.
Abstract
In two cases of parenteral transmission of human immunodeficiency virus type 1 (HIV-1) syncitium-inducing (SI) variants, we previously observed selection for macrophagetropic variants. Although infection of macrophages is generally mediated via CCR5, we found no selection for SI variants that could use CCR5 as coreceptor in addition to CXCR4, suggesting that features other than coreceptor usage account for the macrophagetropism of these transmitted SI HIV-1 variants.Entities:
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Year: 2001 PMID: 11507230 PMCID: PMC115130 DOI: 10.1128/jvi.75.18.8848-8853.2001
Source DB: PubMed Journal: J Virol ISSN: 0022-538X Impact factor: 5.103