| Literature DB >> 11506866 |
R J Leventer1, C Cardoso, D H Ledbetter, W B Dobyns.
Abstract
The LIS1 gene was cloned following the study of children with lissencephaly and cytogenetic abnormalities involving chromosome 17p, however, the role of the LIS1 protein in normal cortical development is not precisely defined. LIS1 is a component of evolutionarily conserved intracellular multiprotein complexes and recent literature shows that these complexes are essential, not only for neuronal migration, but they might also be fundamental components of the machinery for cell proliferation and intracellular transport.Entities:
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Year: 2001 PMID： 11506866 DOI： 10.1016/s0166-2236(00)01887-7
Source DB: PubMed Journal: Trends Neurosci ISSN： 0166-2236 Impact factor: 13.837