E Beinder1, D Schlembach. 1. University Hospital of Erlangen/Nuremberg, Department of Obstetrics, Erlangen, Germany. ernst.beinder@gyn.med.uni-erlangen.de
Abstract
OBJECTIVE: To test the contribution of the endothelium to the maximum vasodilatation in patients with preeclampsia and healthy pregnant controls. METHODS: Laser-Doppler flowmetry, which is a noninvasive method for the continuous measurement of skin blood flow, was used to test the response of skin microcirculation to the above-mentioned stimuli in 14 patients with preeclampsia and 20 normotensive pregnant controls. RESULTS: In normotensive pregnant controls, the reactive hyperemic response after a 3-minute ischemia in the forearm reaches values of 77 +/- 16% of the maximum vasodilatation, which was induced by local hyperthermia of 42C. In patients with preeclampsia, this response was significantly (P <.05) reduced (43 +/- 9%). CONCLUSION: Vascular reactivity is altered in skin vessels of patients with preeclampsia in vivo. This alteration seems to be attributable mainly to the endothelium.
OBJECTIVE: To test the contribution of the endothelium to the maximum vasodilatation in patients with preeclampsia and healthy pregnant controls. METHODS: Laser-Doppler flowmetry, which is a noninvasive method for the continuous measurement of skin blood flow, was used to test the response of skin microcirculation to the above-mentioned stimuli in 14 patients with preeclampsia and 20 normotensive pregnant controls. RESULTS: In normotensive pregnant controls, the reactive hyperemic response after a 3-minute ischemia in the forearm reaches values of 77 +/- 16% of the maximum vasodilatation, which was induced by local hyperthermia of 42C. In patients with preeclampsia, this response was significantly (P <.05) reduced (43 +/- 9%). CONCLUSION: Vascular reactivity is altered in skin vessels of patients with preeclampsia in vivo. This alteration seems to be attributable mainly to the endothelium.
Authors: Aida Hanum Ghulam Rasool; Aisyah Syairah Abdul Rahman; Nor Aliza Abd Ghaffar; Nik Mohd Zaki Nik Mahmood; Abd Rahim Wong Journal: Malays J Med Sci Date: 2010-10
Authors: Janet M Catov; Matthew F Muldoon; Robin E Gandley; Judith Brands; Alisse Hauspurg; Carl A Hubel; Marie Tuft; Mandy Schmella; Gong Tang; W Tony Parks Journal: Hypertension Date: 2021-12-09 Impact factor: 9.897