Literature DB >> 11506503

An orthotopic xenograft model of human nonseminomatous germ cell tumour.

M L Douglas1, K J Boucaut, T M Antalis, C Higgins, M F Pera, M A Stuttgen, D L Nicol.   

Abstract

We have established the first example of an orthotopic xenograft model of human nonseminomatous germ cell tumour (NSGCT). This reproducible model exhibits many clinically relevant features including metastases to the retroperitoneal lymph nodes and lungs, making it an ideal tool for research into the development and progression of testicular germ cell tumours. Copyright 2001 Cancer Research Campaign.

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Year:  2001        PMID： 11506503      PMCID： PMC2364105          DOI： 10.1054/bjoc.2001.1884

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  12 in total

1.  Cultured stem-cells from human testicular teratomas: the nature of human embryonal carcinoma, and its comparison with two types of yolk-sac carcinoma.

Authors:  M F Pera; M J Blasco Lafita; J Mills
Journal:  Int J Cancer       Date:  1987-09-15       Impact factor: 7.396

Review 2.  Pathogenesis of testicular germ cell tumours.

Authors:  L H Looijenga; J W Oosterhuis
Journal:  Rev Reprod       Date:  1999-05

3.  Absence of HeLa cell contamination in 169 cell lines derived from human tumors.

Authors:  J Fogh; W C Wright; J D Loveless
Journal:  J Natl Cancer Inst       Date:  1977-02       Impact factor: 13.506

4.  Development of a high metastatic orthotopic model of human renal cell carcinoma in nude mice: benefits of fragment implantation compared to cell-suspension injection.

Authors:  Z An; P Jiang; X Wang; A R Moossa; R M Hoffman
Journal:  Clin Exp Metastasis       Date:  1999-05       Impact factor: 5.150

5.  Critical factors in the biology of human cancer metastasis: twenty-eighth G.H.A. Clowes memorial award lecture.

Authors:  I J Fidler
Journal:  Cancer Res       Date:  1990-10-01       Impact factor: 12.701

6.  Chemotherapy of Testis Cancer.

Authors: 
Journal:  Cancer Control       Date:  1999-11       Impact factor: 3.302

Review 7.  Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: a bridge to the clinic.

Authors:  R M Hoffman
Journal:  Invest New Drugs       Date:  1999       Impact factor: 3.850

8.  Experimental testicular germ cell tumorigenesis in mouse strains with and without spontaneous tumours differs from development of germ cell tumours of the adult human testis.

Authors:  H Walt; J W Oosterhuis; L C Stevens
Journal:  Int J Androl       Date:  1993-08

9.  Captopril inhibits tumour growth in a xenograft model of human renal cell carcinoma.

Authors:  S I Hii; D L Nicol; D C Gotley; L C Thompson; M K Green; J R Jonsson
Journal:  Br J Cancer       Date:  1998-03       Impact factor: 7.640

10.  Cloned human teratoma cells differentiate into neuron-like cells and other cell types in retinoic acid.

Authors:  S Thompson; P L Stern; M Webb; F S Walsh; W Engstrom; E P Evans; W K Shi; B Hopkins; C F Graham
Journal:  J Cell Sci       Date:  1984-12       Impact factor: 5.285
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  1 in total

1.  Hypermethylation of the 5' CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis.

Authors:  K J Manton; M L Douglas; S Netzel-Arnett; D R Fitzpatrick; D L Nicol; A W Boyd; J A Clements; T M Antalis
Journal:  Br J Cancer       Date:  2005-02-28       Impact factor: 7.640
  1 in total

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