Literature DB >> 11506179

Effects of chronic quercetin treatment on hepatic oxidative status of spontaneously hypertensive rats.

J Duarte1, M Galisteo, M A Ocete, F Pérez-Vizcaino, A Zarzuelo, J Tamargo.   

Abstract

The effects of chronic administration of an oral daily dose of quercetin (10 mg Kg(-1)), the most abundant dietary flavonoid, were investigated on hepatic oxidative status in spontaneously hypertensive rats and normotensive Wistar Kyoto rats. Decreased liver glutathione peroxidase activity, increased liver total glutathione levels and increased both hepatic and plasmatic malondialdehyde concentrations were observed in spontaneously hypertensive rats when compared to Wistar Kyoto rats. In spontaneously hypertensive rats, treatment with quercetin for 5 weeks reduced blood pressure, increased glutathione peroxidase activity and reduced both plasma and hepatic malondialdehyde levels. However, none of these effects were observed in Wistar Kyoto rats. In conclusion, quercetin shows both antihypertensive and antioxidant properties in this model of genetic hypertension.

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Year:  2001        PMID： 11506179     DOI： 10.1023/a:1010956928584

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  36 in total

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Journal:  Biochem Pharmacol       Date:  1999-01-15       Impact factor: 5.858

2.  Effects of antihypertensive drugs on antioxidant enzyme activities and renal function in stroke-prone spontaneously hypertensive rats.

Authors:  I Shou; L N Wang; S Suzuki; M Fukui; Y Tomino
Journal:  Am J Med Sci       Date:  1997-12       Impact factor: 2.378

3.  Dietary flavonoid intake and risk of cardiovascular disease in postmenopausal women.

Authors:  L Yochum; L H Kushi; K Meyer; A R Folsom
Journal:  Am J Epidemiol       Date:  1999-05-15       Impact factor: 4.897

4.  Antioxidant status, lipid peroxidation, mixed function oxidase and UDP-glucuronyl transferase activities in livers from control and DOCA-salt hypertensive male Sprague Dawley rats.

Authors:  L Nicod; S Rodriguez; J M Letang; C Viollon-Abadie; A Jacqueson; A Berthelot; L Richert
Journal:  Mol Cell Biochem       Date:  2000-01       Impact factor: 3.396

Review 5.  The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer.

Authors:  E Middleton; C Kandaswami; T C Theoharides
Journal:  Pharmacol Rev       Date:  2000-12       Impact factor: 25.468

6.  On the mechanism of antithrombotic action of flavonoids.

Authors:  R J Gryglewski; R Korbut; J Robak; J Swies
Journal:  Biochem Pharmacol       Date:  1987-02-01       Impact factor: 5.858

7.  Nicardipine normalizes elevated levels of antioxidant activity in response to xanthine oxidase-induced oxidative stress in hypertensive rat heart.

Authors:  D M Carlos; S Goto; Y Urata; T Iida; S Cho; M Niwa; Y Tsuji; T Kondo
Journal:  Free Radic Res       Date:  1998-08

8.  A comparative study on defense systems for lipid peroxidation by free radicals in spontaneously hypertensive and normotensive rat myocardium.

Authors:  H Ito; M Torii; T Suzuki
Journal:  Comp Biochem Physiol B       Date:  1992-09

9.  Blockade of Poly(ADP-ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis.

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Journal:  Gastroenterology       Date:  1999-02       Impact factor: 22.682

10.  Age-related changes in antioxidant defence mechanisms and peroxidation in isolated hepatocytes from spontaneously hypertensive and normotensive rats.

Authors:  E Véricel; M Narce; L Ulmann; J P Poisson; M Lagarde
Journal:  Mol Cell Biochem       Date:  1994-03-16       Impact factor: 3.396
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  18 in total

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2.  Protective role of quercetin on PCBs-induced oxidative stress and apoptosis in hippocampus of adult rats.

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Journal:  Neurochem Res       Date:  2011-11-30       Impact factor: 3.996

Review 3.  Therapeutic potential of quercetin to decrease blood pressure: review of efficacy and mechanisms.

Authors:  Abigail J Larson; J David Symons; Thunder Jalili
Journal:  Adv Nutr       Date:  2012-01-05       Impact factor: 8.701

4.  Effect of Dietary Doses of Quercetin on Hepatic Drug Metabolizing Enzymes in Spontaneously Hypertensive Rats.

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Journal:  Eur J Drug Metab Pharmacokinet       Date:  2019-12       Impact factor: 2.441

5.  Dietary vitamin C supplementation decreases blood pressure in DOCA-salt hypertensive male Sprague-Dawley rats and this is associated with increased liver oxidative stress.

Authors:  Fatiha Elhaïmeur; Carol Courderot-Masuyer; Laurence Nicod; Catherine Guyon; Lysiane Richert; Alain Berthelot
Journal:  Mol Cell Biochem       Date:  2002-08       Impact factor: 3.396

6.  Quercetin decreases steroidogenic enzyme activity, NF-κB expression, and oxidative stress in cultured Leydig cells exposed to atrazine.

Authors:  Sunny O Abarikwu; Aditya B Pant; Ebenezer O Farombi
Journal:  Mol Cell Biochem       Date:  2012-10-16       Impact factor: 3.396

7.  Effects of quercetin on liver damage in rats with carbon tetrachloride-induced cirrhosis.

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8.  Effects of chronic quercetin treatment on antioxidant defence system and oxidative status of deoxycorticosterone acetate-salt-hypertensive rats.

Authors:  Milagros Galisteo; Maria Francisca García-Saura; Rosario Jiménez; Inmaculada Concepción Villar; Antonio Zarzuelo; Félix Vargas; Juan Duarte
Journal:  Mol Cell Biochem       Date:  2004-04       Impact factor: 3.396

9.  Dual effect of quercetin on rat isolated portal vein smooth muscle contractility.

Authors:  W D Chiwororo; J A Ojewole
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10.  The effects of a multiflavonoid supplement on vascular and hemodynamic parameters following acute exercise.

Authors:  Rebecca M Kappus; Chelsea D Curry; Steve McAnulty; Janice Welsh; David Morris; David C Nieman; Jeffrey Soukup; Scott R Collier
Journal:  Oxid Med Cell Longev       Date:  2011-12-04       Impact factor: 6.543
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