Effect of sojourn at 4,300 m altitude on electroencephalogram and visual evoked response.

The purpose of the present study was to determine the effect of sojourn at high altitude on cerebral electrical activity. Electroencephalographic (EEG) and visual evoked responses (VER) were recorded from seven healthy males under the following conditions: 1) during the first 2-3 h at 4,300 m altitude when Pao2 was maintained at 90 mmHg (control condition), 2) during the first 2-3 h of hypoxia (Pao2 = 40 mmHg), and 3) at 24- to 48-h intervals during the first 9-12 days of hypoxia. Electrode placement was according to the 10-20 International Electrode System. The VER was recorded from an electrode at the inion referred to the left ear. We found no significant changes from control cerebral electrical activity during the first 2-3 h of hypoxia. One subject's VER amplitude was greater than control on the 2nd and 3rd days of hypoxia and a similar change from control was consistently evident in a second subject beginning the 5th day of hypoxia. These changes suggest cortical depression. After the 5th day changes occurred in the remaining subjects which would be consistent with cortical excitation. In three subjects, EEG frequency was increased, amplitude decreased, and/or spiking became evident. In four subjects VER amplitude was reduced. Our findings provide support for the hypothesis that certain behavioral and physiological changes induced by sojourn at altitude could be caused by alterations in central nervous system function.