Literature DB >> 11504625

Journey of the iodide transporter NIS: from its molecular identification to its clinical role in cancer.

C Riedel1, O Dohán, A De la Vieja, C S Ginter, N Carrasco.   

Abstract

The Na+/I- symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of I- in the thyroid, lactating mammary gland, stomach and salivary glands. The presence of NIS in the thyroid is exploited in diagnostic scintigraphic imaging and radioiodide therapy in thyroid cancer. The continued rapid progress in NIS research (aimed at the elucidation of the Na+-dependent I- transport mechanism, the analysis of NIS structure-function relations and the study of the tissue-specific regulation of NIS at all levels), holds potentially far-reaching medical applications beyond thyroid disease, in breast cancer and malignancies in other tissues.

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Year:  2001        PMID： 11504625     DOI： 10.1016/s0968-0004(01)01904-1

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  7 in total

Review 1.  Dual oxidases.

Authors:  Agnes Donkó; Zalán Péterfi; Adrienn Sum; Thomas Leto; Miklós Geiszt
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2005-12-29       Impact factor: 6.237

Review 2.  Nuclear imaging of molecular processes in cancer.

Authors:  Rafael Torres Martin de Rosales; Erik Arstad; Philip J Blower
Journal:  Target Oncol       Date:  2009-09-25       Impact factor: 4.493

3.  Na+ coordination at the Na2 site of the Na+/I- symporter.

Authors:  Giuseppe Ferrandino; Juan Pablo Nicola; Yuly E Sánchez; Ignacia Echeverria; Yunlong Liu; L Mario Amzel; Nancy Carrasco
Journal:  Proc Natl Acad Sci U S A       Date:  2016-08-25       Impact factor: 11.205

Review 4.  The Na+/I- symporter (NIS): mechanism and medical impact.

Authors:  Carla Portulano; Monika Paroder-Belenitsky; Nancy Carrasco
Journal:  Endocr Rev       Date:  2013-12-04       Impact factor: 19.871

Review 5.  The sodium/glucose cotransport family SLC5.

Authors:  Ernest M Wright; Eric Turk
Journal:  Pflugers Arch       Date:  2003-05-14       Impact factor: 3.657

6.  Heterologous expression of membrane proteins: choosing the appropriate host.

Authors:  Florent Bernaudat; Annie Frelet-Barrand; Nathalie Pochon; Sébastien Dementin; Patrick Hivin; Sylvain Boutigny; Jean-Baptiste Rioux; Daniel Salvi; Daphné Seigneurin-Berny; Pierre Richaud; Jacques Joyard; David Pignol; Monique Sabaty; Thierry Desnos; Eva Pebay-Peyroula; Elisabeth Darrouzet; Thierry Vernet; Norbert Rolland
Journal:  PLoS One       Date:  2011-12-21       Impact factor: 3.240

7.  Targeting Novel Sodium Iodide Symporter Interactors ADP-Ribosylation Factor 4 and Valosin-Containing Protein Enhances Radioiodine Uptake.

Authors:  Vicki E Smith; Christopher J McCabe; Alice Fletcher; Martin L Read; Caitlin E M Thornton; Dean P Larner; Vikki L Poole; Katie Brookes; Hannah R Nieto; Mohammed Alshahrani; Rebecca J Thompson; Gareth G Lavery; Iñigo Landa; James A Fagin; Moray J Campbell; Kristien Boelaert; Andrew S Turnell
Journal:  Cancer Res       Date:  2019-10-31       Impact factor: 12.701
  7 in total

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