Literature DB >> 11503958

Bone marrow colony-forming unit assay in cats with naturally occurring myelodysplastic syndromes.

Naho Nagashima1, Masaharu Hisasue2, Katsumi Higashi3, Rui Kano4, Hajime Tsujimoto5, Atsuhiko Hasegawa1.   

Abstract

Feline myelodysplastic syndromes (MDS) has been diagnosed in many cats infected with feline leukemia virus, although the pathogenesis of this hematopoietic deficiency has been unclear. In this study, we assayed the bone marrow erythroid colony-forming units (CFU-E) and granulocyte-machrophage CFUs (CFU-GM) to investigate the pathogenesis of feline MDS. The number of CFU-E colonies was decreased in 4 of 7 cats with MDS, and the number of CFU-GM colonies was also decreased in 4 cats. Furthermore, small colonies of CFU-GM were found in all 7 cases. These findings indicated that refractory cytopenia of feline MDS could be caused by abnormal maturation and differentiation of hematopoietic stem cells in bone marrow, as it is in human MDS. The pathogenesis of feline MDS might be similar to that of human MDS.

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Year:  2001        PMID： 11503958     DOI： 10.1007/BF02994006

Source DB:  PubMed          Journal:  Int J Hematol        ISSN： 0925-5710            Impact factor:   2.490


  10 in total

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Authors:  N N Iscove; F Sieber
Journal:  Exp Hematol       Date:  1975-01       Impact factor: 3.084

2.  Is apoptosis a massive process in myelodysplastic syndromes?

Authors:  P Lepelley; L Campergue; N Grardel; C Preudhomme; A Cosson; P Fenaux
Journal:  Br J Haematol       Date:  1996-11       Impact factor: 6.998

3.  Proposed criteria for classification of acute myeloid leukemia in dogs and cats.

Authors:  Nemi C. Jain; Julia T. Blue; Carol B. Grindem; John W. Harvey; Gary J. Kociba; Janver D. Krehbiel; Kenneth S. Latimer; Rose E. Raskin; Mary A. Thrall; Joseph G. Zinkl
Journal:  Vet Clin Pathol       Date:  1991       Impact factor: 1.180

Review 4.  Apoptosis as a cell biological abnormality in myelodysplasia.

Authors:  Y Yoshida; H Kawabata; N Anzai; K Tohyama
Journal:  Pathol Biol (Paris)       Date:  1997-09

5.  A hematological study on thirteen cats with myelodysplastic syndrome.

Authors:  T Shimoda; N Shiranaga; T Mashita; A Hasegawa
Journal:  J Vet Med Sci       Date:  2000-01       Impact factor: 1.267

6.  Molecular cloning and characterization of a defective recombinant feline leukaemia virus associated with myeloid leukaemia.

Authors:  T Tzavaras; M Stewart; A McDougall; R Fulton; N Testa; D E Onions; J C Neil
Journal:  J Gen Virol       Date:  1990-02       Impact factor: 3.891

7.  Clonality analysis of various hematopoietic disorders in cats naturally infected with feline leukemia virus.

Authors:  M Hisasue; K Nishigaki; H Katae; K Yuri; T Mizuno; Y Fujino; A Setoguchi; A Hasegawa; T Watari; K Masuda; K Ohno; H Tsujimoto
Journal:  J Vet Med Sci       Date:  2000-10       Impact factor: 1.267

Review 8.  World Health Organization classification of the acute leukemias and myelodysplastic syndrome.

Authors:  J M Bennett
Journal:  Int J Hematol       Date:  2000-08       Impact factor: 2.490

9.  Proposals for the classification of the myelodysplastic syndromes.

Authors:  J M Bennett; D Catovsky; M T Daniel; G Flandrin; D A Galton; H R Gralnick; C Sultan
Journal:  Br J Haematol       Date:  1982-06       Impact factor: 6.998

10.  Erythroid and granulocyte-macrophage colony formation in myelodysplastic syndromes.

Authors:  T Ruutu; S Partanen; R Lintula; L Teerenhovi; S Knuutila
Journal:  Scand J Haematol       Date:  1984-04
  10 in total
  1 in total

1.  A cat with myelodysplastic syndrome by administration of the methylation inhibitor Azacytidine.

Authors:  Masaharu Hisasue; Mina Tanaka; Sakurako Neo
Journal:  J Vet Med Sci       Date:  2021-12-06       Impact factor: 1.267
  1 in total

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