Literature DB >> 11503846

The Danish 1905 cohort: a genetic-epidemiological nationwide survey.

H Nybo1, D Gaist, B Jeune, L Bathum, M McGue, J W Vaupel, K Christensen.   

Abstract

OBJECTIVES: The authors studied nonagenarians, a rapidly growing age group whose cognitive and physical abilities have yet to be investigated systematically.
METHODS: All Danes born in 1905 were invited to participate in a home-based 2-hour multidimensional interview, including cognitive and physical performance tests and collection of DNA, carried out by lay interviewers. Population-based registers were used to evaluate representativeness.
RESULTS: There were 2,262 participants. A total of 1,632 (72%) gave a DNA sample. Participants and nonparticipants were highly comparable with regard to marital status, institutionalization, and hospitalization patterns, but men and rural area residents were more likely to participate. Six months after the survey began, 7.2% of the participants and 11.8% of the nonparticipants had died. DISCUSSION: Despite the known difficulties of conducting surveys among the extremely old, it was possible to conduct a nationwide survey, including collection of DNA, among more than 2,000 fairly nonselected nonagenarians using lay interviewers.

Entities:  

Mesh:

Year:  2001        PMID: 11503846     DOI: 10.1177/089826430101300102

Source DB:  PubMed          Journal:  J Aging Health        ISSN: 0898-2643


  53 in total

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Journal:  Exp Gerontol       Date:  2012-03-03       Impact factor: 4.032

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6.  The Mn-superoxide dismutase single nucleotide polymorphism rs4880 and the glutathione peroxidase 1 single nucleotide polymorphism rs1050450 are associated with aging and longevity in the oldest old.

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7.  Cohort changes in cognitive function among Danish centenarians. A comparative study of 2 birth cohorts born in 1895 and 1905.

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8.  Analyzing age-specific genetic effects on human extreme age survival in cohort-based longitudinal studies.

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10.  Birth cohort differences in the prevalence of longevity-associated variants in APOE and FOXO3A in Danish long-lived individuals.

Authors:  Marianne Nygaard; Rune Lindahl-Jacobsen; Mette Soerensen; Jonas Mengel-From; Karen Andersen-Ranberg; Bernard Jeune; James W Vaupel; Qihua Tan; Lene Christiansen; Kaare Christensen
Journal:  Exp Gerontol       Date:  2014-05-05       Impact factor: 4.032

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