Literature DB >> 11502751

Identification and characterization of a novel inositol hexakisphosphate kinase.

A Saiardi1, E Nagata, H R Luo, A M Snowman, S H Snyder.   

Abstract

The inositol pyrophosphate disphosphoinositol pentakisphosphate (PP-InsP(3)/InsP(7)) is formed in mammals by two recently cloned inositol hexakiphosphate kinases, InsP(6)K1 and InsP(6)K2 (Saiardi, A., Erdjument-Bromage, H., Snowman, A. M., Tempst, P., and Snyder, S. H. (1999) Curr. Biol. 9, 1323-1326). We now report the identification, cloning, and characterization of a third InsP(7) forming enzyme designated InsP(6)K3. InsP(6)K3 displays 50 and 45% sequence identity to InsP(6)K1 and InsP(6)K2, respectively, with a smaller mass (46 kDa) and a more basic character than the other two enzymes. InsP(6)K3 is most enriched in the brain where its localization resembles InsP(6)K1 and InsP(6)K2. Intracellular disposition discriminates the three enzymes with InsP(6)K2 being exclusively nuclear, InsP(6)K3 predominating in the cytoplasm, and InsP(6)K1 displaying comparable nuclear and cytosolic densities.

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Year:  2001        PMID： 11502751     DOI： 10.1074/jbc.M106842200

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  65 in total

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Authors:  Seyun Kim; Sangwon F Kim; David Maag; Micah J Maxwell; Adam C Resnick; Krishna R Juluri; Anutosh Chakraborty; Michael A Koldobskiy; Seung Hun Cha; Roxanne Barrow; Adele M Snowman; Solomon H Snyder
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Review 6.  Roles for inositol polyphosphate kinases in the regulation of nuclear processes and developmental biology.

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7.  HSP90 regulates cell survival via inositol hexakisphosphate kinase-2.

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8.  Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2.

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Journal:  Mol Cell       Date:  2014-03-20       Impact factor: 17.970

9.  A conserved protein motif is required for full modulatory activity of negative elongation factor subunits NELF-A and NELF-B in modifying glucocorticoid receptor-regulated gene induction properties.

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10.  Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases.

Authors:  Hongying Lin; Peter C Fridy; Anthony A Ribeiro; Jae H Choi; Deb K Barma; Günter Vogel; J R Falck; Stephen B Shears; John D York; Georg W Mayr
Journal:  J Biol Chem       Date:  2008-11-03       Impact factor: 5.157
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