Literature DB >> 1150261

Pyruvate kinase isozyme patterns of human neoplastic, fetal and adult tissues.

R Kamel, F Schwarzfischer.   

Abstract

A method of starch gel electrophoresis is described which enables detection of 6 isozymes of human pyruvate kinase (PK, E.C.2.7.1.40). Comparing the PK-isozyme patterns of 53 diverse human tumors with those of normal adult and fetal organ tissues, it was found that the isozyme PK I is predominant in all malignant tumors as well as in almost all fetal organs.

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Year:  1975        PMID: 1150261     DOI: 10.1007/bf00272484

Source DB:  PubMed          Journal:  Humangenetik        ISSN: 0018-7348


  4 in total

1.  MULTIPLE FORMS OF ENZYMES: TISSUE, ONTOGENETIC, AND SPECIES SPECIFIC PATTERNS.

Authors:  C L Markert; F Møller
Journal:  Proc Natl Acad Sci U S A       Date:  1959-05       Impact factor: 11.205

2.  Comparative kinetic study of human pyruvate kinases isolated from adult and fetal livers and from hepatoma.

Authors:  D Balinsky; E Cayanis; I Bersohn
Journal:  Biochemistry       Date:  1973-02-27       Impact factor: 3.162

Review 3.  Recent trends in cancer biochemistry: the importance of studies on fetal tissue.

Authors:  V R Potter
Journal:  Proc Can Cancer Conf       Date:  1969

4.  Metabolic regulation and enzyme alterations in the Morris hepatomas.

Authors:  F A Farina; R C Adelman; C H Lo; H P Morris; S Weinhouse
Journal:  Cancer Res       Date:  1968-09       Impact factor: 12.701

  4 in total
  5 in total

1.  Multiple forms of enolase (E.C. 4.2.1.11): their distribution in human tissues.

Authors:  R Kamel; F Schwarzfischer
Journal:  Humangenetik       Date:  1975-07-23

Review 2.  PKM2, cancer metabolism, and the road ahead.

Authors:  Talya L Dayton; Tyler Jacks; Matthew G Vander Heiden
Journal:  EMBO Rep       Date:  2016-11-17       Impact factor: 8.807

3.  Hexokinase isozymes in human neoplastic and fetal tissues: the existence of hexokinase II in malignant tumors and in placenta.

Authors:  R Kamel; F Schwarzfischer
Journal:  Humangenetik       Date:  1975-11-06

Review 4.  Role of Pyruvate Kinase M2 (PKM2) in Cardiovascular Diseases.

Authors:  Mohd Rihan; Shyam Sunder Sharma
Journal:  J Cardiovasc Transl Res       Date:  2022-09-30       Impact factor: 3.216

Review 5.  Metabolic Reprogramming in Thyroid Carcinoma.

Authors:  Raquel Guimaraes Coelho; Rodrigo S Fortunato; Denise P Carvalho
Journal:  Front Oncol       Date:  2018-03-23       Impact factor: 6.244

  5 in total

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