Literature DB >> 11502545

Emergence of a pneumococcal clone with cephalosporin resistance and penicillin susceptibility.

A M Smith1, R F Botha, H J Koornhof, K P Klugman.   

Abstract

We report two South African serotype 6B pneumococcal isolates with cephalosporin resistance, yet with susceptibility to penicillin. DNA fingerprinting revealed that they were clonal in origin. pbp 2X and 1A genes showed major alterations typical of cephalosporin-resistant pneumococci. The pbp 2B gene was completely unaltered, explaining the penicillin susceptibility of the isolates.

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Year:  2001        PMID： 11502545      PMCID： PMC90708          DOI： 10.1128/AAC.45.9.2648-2650.2001

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

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Authors:  R Muñoz; C G Dowson; M Daniels; T J Coffey; C Martin; R Hakenbeck; B G Spratt
Journal:  Mol Microbiol       Date:  1992-09       Impact factor: 3.501

2.  REGULATION OF THE TRANSFORMABILITY OF PHEUMOCOCCAL CULTURES BY MACROMOLECULAR CELL PRODUCTS.

Authors:  A TOMASZ; R D HOTCHKISS
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3.  Horizontal transfer of penicillin-binding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae.

Authors:  C G Dowson; A Hutchison; J A Brannigan; R C George; D Hansman; J Liñares; A Tomasz; J M Smith; B G Spratt
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4.  Genetic diversity of penicillin-binding protein 2B and 2X genes from Streptococcus pneumoniae in South Africa.

Authors:  A M Smith; K P Klugman; T J Coffey; B G Spratt
Journal:  Antimicrob Agents Chemother       Date:  1993-09       Impact factor: 5.191

Review 5.  Penicillin-binding proteins and the mechanism of action of beta-lactam antibiotics.

Authors:  D J Waxman; J L Strominger
Journal:  Annu Rev Biochem       Date:  1983       Impact factor: 23.643

6.  Nucleotide sequences of genes encoding penicillin-binding proteins from Streptococcus pneumoniae and Streptococcus oralis with high homology to Escherichia coli penicillin-binding proteins 1a and 1b.

Authors:  C Martin; T Briese; R Hakenbeck
Journal:  J Bacteriol       Date:  1992-07       Impact factor: 3.490

7.  Inhibition of the expression of penicillin resistance in Streptococcus pneumoniae by inactivation of cell wall muropeptide branching genes.

Authors:  S R Filipe; A Tomasz
Journal:  Proc Natl Acad Sci U S A       Date:  2000-04-25       Impact factor: 11.205

8.  Penicillin-binding proteins of multiply antibiotic-resistant South African strains of Streptococcus pneumoniae.

Authors:  S Zighelboim; A Tomasz
Journal:  Antimicrob Agents Chemother       Date:  1980-03       Impact factor: 5.191

9.  Interspecies recombinational events during the evolution of altered PBP 2x genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae.

Authors:  G Laible; B G Spratt; R Hakenbeck
Journal:  Mol Microbiol       Date:  1991-08       Impact factor: 3.501

10.  Gene localization, size, and physical map of the chromosome of Streptococcus pneumoniae.

Authors:  A M Gasc; L Kauc; P Barraillé; M Sicard; S Goodgal
Journal:  J Bacteriol       Date:  1991-11       Impact factor: 3.490
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Authors:  James A Karlowsky; Mark E Jones; Deborah C Draghi; Daniel F Sahm
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4.  Genotypes of invasive pneumococcal isolates recently recovered from Italian patients.

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