Literature DB >> 115013

Ethanol drinking by rhesus monkeys with concurrent access to water.

J E Henningfield, R A Meisch.   

Abstract

Three monkeys were provided concurrent access to water and ethanol in concentrations of either 8, 16 or 32% (w/v) during daily 3-hr sessions. The monkeys were those for whom ethanol had been established as a reinforcer in an earlier study in which only ethanol or water was available. Ethanol was preferred to water at all concentrations and volume of ethanol consumed was inversely related to ethanol concentration. Quantity of ethanol (g/kg of body wt.) consumed remained relatively constant, and blood ethanol determinations confirmed that the monkeys were drinking ethanol. Water drinking occurred at negligible levels except by one monkey at 16 and 32% who followed ethanol drinking bouts by water bouts (chasers) in a manner similar to that reported in other studies. Two monkeys were also provided concurrent access to 8% ethanol and water during 23-hr daily sessions. Under these conditions, ethanol was consumed every few hours to the near exclusion of water. The significance of this study lies largely in its procedure; that is, the development and application of a concurrent water-ethanol preparation in which ethanol serves as a reinforcer for rhesus monkeys. This preparation should be useful in the evaluation of a wide range of factors suspected to control alcoholic drinking.

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Year:  1979        PMID: 115013     DOI: 10.1016/0091-3057(79)90332-0

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN: 0091-3057            Impact factor:   3.533


  11 in total

1.  Relation between choice of ethanol concentration and response rates under progressive- and fixed-ratio schedules: studies with rhesus monkeys.

Authors:  Thomas H Gomez; Richard A Meisch
Journal:  Psychopharmacology (Berl)       Date:  2003-06-12       Impact factor: 4.530

2.  The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice.

Authors:  Clyde W Hodge; Michael F Miles; Amanda C Sharko; Rebekah A Stevenson; Jennie R Hillmann; Veronique Lepoutre; Joyce Besheer; Jason P Schroeder
Journal:  Psychopharmacology (Berl)       Date:  2005-11-15       Impact factor: 4.530

3.  Oral self-administration of pentobarbital by rhesus monkeys: relative reinforcing effects under concurrent fixed-ratio schedules.

Authors:  R A Meisch; G A Lemaire
Journal:  J Exp Anal Behav       Date:  1988-07       Impact factor: 2.468

4.  Mouse strain differences in operant self-administration of ethanol.

Authors:  G I Elmer; R A Meisch; F R George
Journal:  Behav Genet       Date:  1987-09       Impact factor: 2.805

5.  Social separation increases alcohol consumption in rhesus monkeys.

Authors:  G W Kraemer; W T McKinney
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

6.  Oral drug self-administration in rhesus monkeys: interactions between drug amount and fixed-ratio size.

Authors:  G A Lemaire; R A Meisch
Journal:  J Exp Anal Behav       Date:  1985-11       Impact factor: 2.468

7.  Self-administration of orally-delivered phencyclidine and ethanol under concurrent fixed-ratio schedules in rhesus monkeys.

Authors:  M E Carroll
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

8.  Alcoholic-like drinking in simian social groups.

Authors:  T J Crowley; A E Andrews
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

9.  Oral self-administration of triazolam, diazepam and ethanol in the baboon: drug reinforcement and benzodiazepine physical dependence.

Authors:  N A Ator; R R Griffiths
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

10.  Oral self-administration of phencyclidine analogs by rhesus monkeys: conditioned taste and visual reinforcers.

Authors:  M E Carroll
Journal:  Psychopharmacology (Berl)       Date:  1982       Impact factor: 4.530

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