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Literature DB >> 11500478

Cryptosporidium parvum infection requires host cell actin polymerization.

D A Elliott¹, D J Coleman, M A Lane, R C May, L M Machesky, D P Clark.

Abstract

The intracellular protozoan parasite Cryptosporidium parvum accumulates host cell actin at the interface between the parasite and the host cell cytoplasm. Here we show that the actin polymerizing proteins Arp2/3, vasodilator-stimulated phosphoprotein (VASP), and neural Wiskott Aldrich syndrome protein (N-WASP) are present at this interface and that host cell actin polymerization is necessary for parasite infection.

Entities: Disease Species

Mesh：

Substances：

Year: 2001 PMID： 11500478 PMCID： PMC98718 DOI： 10.1128/IAI.69.9.5940-5942.2001

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

32 in total

1. Involvement of the Arp2/3 complex in phagocytosis mediated by FcgammaR or CR3.

Authors: R C May; E Caron; A Hall; L M Machesky
Journal: Nat Cell Biol Date: 2000-04 Impact factor: 28.824

2. Enteropathogenic E. coli acts through WASP and Arp2/3 complex to form actin pedestals.

Authors: D Kalman; O D Weiner; D L Goosney; J W Sedat; B B Finlay; A Abo; J M Bishop
Journal: Nat Cell Biol Date: 1999-10 Impact factor: 28.824

Review 3. Exploitation of mammalian host cell functions by bacterial pathogens.

Authors: B B Finlay; P Cossart
Journal: Science Date: 1997-05-02 Impact factor: 47.728

4. Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex.

Authors: K E Prehoda; J A Scott; R D Mullins; W A Lim
Journal: Science Date: 2000-10-27 Impact factor: 47.728

5. The Arp2/3 complex is essential for the actin-based motility of Listeria monocytogenes.

Authors: R C May; M E Hall; H N Higgs; T D Pollard; T Chakraborty; J Wehland; L M Machesky; A S Sechi
Journal: Curr Biol Date: 1999-07-15 Impact factor: 10.834

6. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins.

Authors: L M Machesky; E Reeves; F Wientjes; F J Mattheyse; A Grogan; N F Totty; A L Burlingame; J J Hsuan; A W Segal
Journal: Biochem J Date: 1997-11-15 Impact factor: 3.857

Review 7. New insights into human cryptosporidiosis.

Authors: D P Clark
Journal: Clin Microbiol Rev Date: 1999-10 Impact factor: 26.132

8. Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite.

Authors: J M Dobrowolski; L D Sibley
Journal: Cell Date: 1996-03-22 Impact factor: 41.582

9. Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate.

Authors: R Rohatgi; H Y Ho; M W Kirschner
Journal: J Cell Biol Date: 2000-09-18 Impact factor: 10.539

10. Cytoskeletal rearrangements accompanying salmonella entry into epithelial cells.

Authors: B B Finlay; S Ruschkowski; S Dedhar
Journal: J Cell Sci Date: 1991-06 Impact factor: 5.285

32 in total

Review 1. Cytoskeleton of apicomplexan parasites.

Authors: Naomi S Morrissette; L David Sibley
Journal: Microbiol Mol Biol Rev Date: 2002-03 Impact factor: 11.056

2. Cholangiocyte myosin IIB is required for localized aggregation of sodium glucose cotransporter 1 to sites of Cryptosporidium parvum cellular invasion and facilitates parasite internalization.

Authors: Steven P O'Hara; Gabriella B Gajdos; Christy E Trussoni; Patrick L Splinter; Nicholas F LaRusso
Journal: Infect Immun Date: 2010-05-10 Impact factor: 3.441

10. Cdc42 and the actin-related protein/neural Wiskott-Aldrich syndrome protein network mediate cellular invasion by Cryptosporidium parvum.

Authors: Xian-Ming Chen; Bing Q Huang; Patrick L Splinter; James D Orth; Daniel D Billadeau; Mark A McNiven; Nicholas F LaRusso
Journal: Infect Immun Date: 2004-05 Impact factor: 3.441

Cryptosporidium parvum infection requires host cell actin polymerization.

1. Involvement of the Arp2/3 complex in phagocytosis mediated by FcgammaR or CR3.

2. Enteropathogenic E. coli acts through WASP and Arp2/3 complex to form actin pedestals.

Review 3. Exploitation of mammalian host cell functions by bacterial pathogens.

4. Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex.

5. The Arp2/3 complex is essential for the actin-based motility of Listeria monocytogenes.

6. Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins.

Review 7. New insights into human cryptosporidiosis.

8. Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite.

9. Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate.

10. Cytoskeletal rearrangements accompanying salmonella entry into epithelial cells.

Review 1. Cytoskeleton of apicomplexan parasites.

2. Cholangiocyte myosin IIB is required for localized aggregation of sodium glucose cotransporter 1 to sites of Cryptosporidium parvum cellular invasion and facilitates parasite internalization.

3. Host cell fate on Cryptosporidium parvum egress from MDCK cells.

4. Gliding motility leads to active cellular invasion by Cryptosporidium parvum sporozoites.

Review 5. Survival of protozoan intracellular parasites in host cells.

6. Interaction of Cryptosporidium hominis and Cryptosporidium parvum with primary human and bovine intestinal cells.

7. Disruption of the Rickettsia rickettsii Sca2 autotransporter inhibits actin-based motility.

8. Cytoskeletal changes in Eimeria bovis-infected host endothelial cells during first merogony.

9. Host cell tropism underlies species restriction of human and bovine Cryptosporidium parvum genotypes.

10. Cdc42 and the actin-related protein/neural Wiskott-Aldrich syndrome protein network mediate cellular invasion by Cryptosporidium parvum.