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Literature DB >> 1149954

Increased kidney size and glomerular filtration rate in untreated juvenile diabetes: normalization by insulin-treatment.

Abstract

Glomerular filtration rate (GFR), renal plasma flow (RPF) and roentigenographic kiendy size were measured in six newly diagnosed male diabetics with a mean age of 25 years. Glomerular filtration rate was elevated before treatment to the same extent as found previously. A significant fall in both kidney size and glomerular filtration rate was found after treatment with insulin for 3 months. These results support further the concept that there is a basal connection between enlarged kidneys and the elevated GFR of early diabetes.

Entities: Disease Gene

Mesh：

Substances：
Insulin

Year: 1975 PMID： 1149954 DOI： 10.1007/bf00422325

Source DB: PubMed Journal: Diabetologia ISSN： 0012-186X Impact factor: 10.122

15 in total

1. [Functional microangiopathy of the kidneys in treated diabetes mellitus in children].

Authors: G STALDER; R SCHMID
Journal: Dtsch Med Wochenschr Date: 1960-02-26 Impact factor: 0.628

2. Kidney size and its deviation from normal in acute renal failure.

Authors: H MOELL
Journal: Acta Radiol Suppl Date: 1961

3. Renal function studies and autopsy report in a patient with gigantism and acromegaly.

Authors: H GERSHBERG; H O HEINEMANN; H H STUMPF
Journal: J Clin Endocrinol Metab Date: 1957-03 Impact factor: 5.958

4. Glomerular size and structure in diabetes mellitus. I. Early abnormalities.

Authors: R Osterby; H J Gundersen
Journal: Diabetologia Date: 1975-06 Impact factor: 10.122

5. Kidney function and glomerular permeability to macromolecules in juvenile diabetes with special reference to early changes.

Authors: C E Mogensen
Journal: Dan Med Bull Date: 1972-09

6. Elevated glomerular filtration rate in insulin-treated short-term diabetes. Non-dependence on blood sugar value.

Authors: C E Mogensen
Journal: Acta Med Scand Date: 1973-12

7. Maximum tubular reabsorption capacity for glucose and renal hemodynamcis during rapid hypertonic glucose infusion in normal and diabetic subjects.

Authors: C E Mogensen
Journal: Scand J Clin Lab Invest Date: 1971-09 Impact factor: 1.713

8. Abnormally increased glomerular filtration rate in short-term insulin-treated diabetic subjects.

Authors: J Ditzel; M Schwartz
Journal: Diabetes Date: 1967-04 Impact factor: 9.461

9. Abnormal serum growth hormone response to exercise in juvenile diabetics.

Authors: A P Hansen
Journal: J Clin Invest Date: 1970-08 Impact factor: 14.808

10. Abnormal glomerular filtration rate, renal plasma flow, and renal protein excretion in recent and short-term diabetics.

Authors: J Ditzel; K Junker
Journal: Br Med J Date: 1972-04-01

62 in total

Review 1. Autocrine and paracrine mechanisms in the early stages of diabetic nephropathy.

Authors: G Pugliese; F Pricci; G Romeo; G Leto; L Amadio; C Iacobini; U Di Mario
Journal: J Endocrinol Invest Date: 1999-10 Impact factor: 4.256

Review 2. Management of diabetic nephropathy.

Authors: L Foggensteiner; S Mulroy; J Firth
Journal: J R Soc Med Date: 2001-05 Impact factor: 5.344

10. The influence of human C-peptide on renal function and glucose utilization in type 1 (insulin-dependent) diabetic patients.

Authors: B L Johansson; S Sjöberg; J Wahren
Journal: Diabetologia Date: 1992-02 Impact factor: 10.122

Increased kidney size and glomerular filtration rate in untreated juvenile diabetes: normalization by insulin-treatment.

1. [Functional microangiopathy of the kidneys in treated diabetes mellitus in children].

2. Kidney size and its deviation from normal in acute renal failure.

3. Renal function studies and autopsy report in a patient with gigantism and acromegaly.

4. Glomerular size and structure in diabetes mellitus. I. Early abnormalities.

5. Kidney function and glomerular permeability to macromolecules in juvenile diabetes with special reference to early changes.

6. Elevated glomerular filtration rate in insulin-treated short-term diabetes. Non-dependence on blood sugar value.

7. Maximum tubular reabsorption capacity for glucose and renal hemodynamcis during rapid hypertonic glucose infusion in normal and diabetic subjects.

8. Abnormally increased glomerular filtration rate in short-term insulin-treated diabetic subjects.

9. Abnormal serum growth hormone response to exercise in juvenile diabetics.

10. Abnormal glomerular filtration rate, renal plasma flow, and renal protein excretion in recent and short-term diabetics.

Review 1. Autocrine and paracrine mechanisms in the early stages of diabetic nephropathy.

Review 2. Management of diabetic nephropathy.

3. Glomerular filtration rate and kidney blood flow in alloxan and streptozotocin diabetic rats.

4. The treatment of diabetic kidney disease.

5. Factors related to renal haemodynamics in young type-1 diabetes mellitus patients.

Review 6. The clinical significance of hyperfiltration in diabetes.

7. Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose.

8. Are the 'second generation' oral hypoglycemic agents really different?

9. Expression of nitric oxide synthase in macula densa in streptozotocin diabetic rats.

10. The influence of human C-peptide on renal function and glucose utilization in type 1 (insulin-dependent) diabetic patients.