Literature DB >> 11498870

[Structure determination of new antifungal antibiotics, polaramycins A and B].

W Meng1, W Z Jin.   

Abstract

Antifungal antibiotics, polaramycins A and B have been isolated from the culture of Streptomyces hygroscopicus LP-93. Polaramycins A and B are 36-membered polyol macrolide antibiotics containing hemiacetal monoester of malonic acid and guanidyl groups. Based on spectral evidence including UV, IR, FABMS, 1HNMR, 13CNMR, DEPT, 1H-1H COSY, HETCOR, HMBC, the structure of polaramycins A and B have been assigned as shown in Fig 1 (A, R = H; B, R = CH3).

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Year:  1997        PMID： 11498870

Source DB:  PubMed          Journal:  Yao Xue Xue Bao        ISSN： 0513-4870


  3 in total

1.  PM100117 and PM100118, new antitumor macrolides produced by a marine Streptomyces caniferus GUA-06-05-006A.

Authors:  Marta Pérez; Carmen Schleissner; Rogelio Fernández; Pilar Rodríguez; Fernando Reyes; Paz Zuñiga; Fernando de la Calle; Carmen Cuevas
Journal:  J Antibiot (Tokyo)       Date:  2015-12-09       Impact factor: 2.649

2.  Characterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivative.

Authors:  Raúl García Salcedo; Carlos Olano; Cristina Gómez; Rogelio Fernández; Alfredo F Braña; Carmen Méndez; Fernando de la Calle; José A Salas
Journal:  Microb Cell Fact       Date:  2016-02-22       Impact factor: 5.328

Review 3.  Guanidine-Containing Polyhydroxyl Macrolides: Chemistry, Biology, and Structure-Activity Relationship.

Authors:  Xiaoyuan Song; Ganjun Yuan; Peibo Li; Sheng Cao
Journal:  Molecules       Date:  2019-10-30       Impact factor: 4.411
  3 in total

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