Literature DB >> 11498827

HER-2 and choice of adjuvant chemotherapy in breast cancer.

S Paik1, C Park.   

Abstract

The amplification or overexpression of HER-2 is a recognized prognostic marker that is associated with poor survival for patients with node-positive breast cancer. Several studies have demonstrated that HER-2 may serve to direct the selection of optimal adjuvant chemotherapy. This article provides a critical review of the studies that offer evidence for the role of HER-2 as a predictor of response to chemotherapy.

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Year:  2001        PMID: 11498827     DOI: 10.1016/s0093-7754(01)90127-7

Source DB:  PubMed          Journal:  Semin Oncol        ISSN: 0093-7754            Impact factor:   4.929


  2 in total

1.  Amplification of a 280-kilobase core region at the ERBB2 locus leads to activation of two hypothetical proteins in breast cancer.

Authors:  Päivikki Kauraniemi; Tuula Kuukasjärvi; Guido Sauter; Anne Kallioniemi
Journal:  Am J Pathol       Date:  2003-11       Impact factor: 4.307

2.  Differential gene expression patterns in HER2/neu-positive and -negative breast cancer cell lines and tissues.

Authors:  Katherine S Wilson; Helen Roberts; Russell Leek; Adrian L Harris; Joseph Geradts
Journal:  Am J Pathol       Date:  2002-10       Impact factor: 4.307

  2 in total

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