Literature DB >> 11498400

The role of efflux in macrolide resistance.

Ping Zhong1, Virginia D. Shortridge.   

Abstract

Efflux is one of the major resistance mechanisms for macrolide antibiotics observed in both laboratory and clinical settings. This review summarizes the recent research on two major macrolide efflux pumps: Mef in Gram-positive organisms and Acr-AB-TolC in Haemophilus influenzae and Escherichia coli. The roles of pumps in macrolide resistance and the new advances / strategies to overcome efflux are discussed. Copyright 2000 Harcourt Publishers Ltd.

Entities:  

Year:  2000        PMID： 11498400     DOI： 10.1054/drup.2000.0175

Source DB:  PubMed          Journal:  Drug Resist Updat        ISSN： 1368-7646            Impact factor:   18.500


  15 in total

1.  Phenotypes and genotypes of erythromycin-resistant pneumococci in Italy.

Authors:  Maria Pia Montanari; Marina Mingoia; Ileana Cochetti; Pietro Emanuele Varaldo
Journal:  J Clin Microbiol       Date:  2003-01       Impact factor: 5.948

2.  Expression of the mef(E) gene encoding the macrolide efflux pump protein increases in Streptococcus pneumoniae with increasing resistance to macrolides.

Authors:  Aleksandra K Wierzbowski; Dave Boyd; Michael Mulvey; Daryl J Hoban; George G Zhanel
Journal:  Antimicrob Agents Chemother       Date:  2005-11       Impact factor: 5.191

3.  A novel efflux system in inducibly erythromycin-resistant strains of Streptococcus pyogenes.

Authors:  Eleonora Giovanetti; Andrea Brenciani; Roberto Burioni; Pietro Emanuele Varaldo
Journal:  Antimicrob Agents Chemother       Date:  2002-12       Impact factor: 5.191

4.  Novel macrolide-specific ABC-type efflux transporter in Escherichia coli.

Authors:  N Kobayashi; K Nishino; A Yamaguchi
Journal:  J Bacteriol       Date:  2001-10       Impact factor: 3.490

5.  Multicenter study of the mechanisms of resistance and clonal relationships of Streptococcus agalactiae isolates resistant to macrolides, lincosamides, and ketolides in Spain.

Authors:  J J Gonzalez; A Andreu
Journal:  Antimicrob Agents Chemother       Date:  2005-06       Impact factor: 5.191

6.  Identification, cloning, and functional characterization of EmrD-3, a putative multidrug efflux pump of the major facilitator superfamily from Vibrio cholerae O395.

Authors:  Kenneth P Smith; Sanath Kumar; Manuel F Varela
Journal:  Arch Microbiol       Date:  2009-10-30       Impact factor: 2.552

Review 7.  Efflux-mediated drug resistance in bacteria.

Authors:  Xian-Zhi Li; Hiroshi Nikaido
Journal:  Drugs       Date:  2004       Impact factor: 9.546

8.  Emergence of macrolide resistance in throat culture isolates of group a streptococci in Ontario, Canada, in 2001.

Authors:  Kevin C Katz; Allison J McGeer; Carla L Duncan; Aisha Ashi-Sulaiman; Barbara M Willey; Alicia Sarabia; Jacquie McCann; Sylvia Pong-Porter; Yana Rzayev; Joyce S de Azavedo; Donald E Low
Journal:  Antimicrob Agents Chemother       Date:  2003-07       Impact factor: 5.191

9.  Bioassay-guided evolution of glycosylated macrolide antibiotics in Escherichia coli.

Authors:  Ho Young Lee; Chaitan Khosla
Journal:  PLoS Biol       Date:  2007-02       Impact factor: 8.029

10.  Antibiotic activity of telithromycin and comparators against bacterial pathogens isolated from 3,043 patients with acute exacerbation of chronic bronchitis.

Authors:  Sanjay Sethi; Antonio Anzueto; David J Farrell
Journal:  Ann Clin Microbiol Antimicrob       Date:  2005-03-08       Impact factor: 3.944
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