| Literature DB >> 11497346 |
Abstract
The phosphorodiamidate morpholino oligomers (PMOs) are a distinct class of oligonucleotide analogs. They bind to RNA and efficiently interfere with gene expression in a sequence-specific manner. Their non-ionic character combined with resistance to degradation in the body offer efficacy with minimal toxicity. Hence, the PMOs are emerging as an excellent approach to therapeutics that can be rationally designed based on target gene sequence data.Entities:
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Year: 2001 PMID： 11497346
Source DB: PubMed Journal: Curr Opin Mol Ther ISSN： 1464-8431