Literature DB >> 11496927

Maxi-K potassium channels: form, function, and modulation of a class of endogenous regulators of intracellular calcium.

V K Gribkoff1, J E Starrett, S I Dworetzky.   

Abstract

Large-conductance calcium-activated (maxi-K, BK) potassium channels are widely distributed in the brain. Maxi-K channels function as neuronal calcium sensors and contribute to the control of cellular excitability and the regulation of neurotransmitter release. Little is currently known of any significant role of maxi-K channels in the genesis of neurological disease. Recent advances in the molecular biology and pharmacology of these channels have revealed sources of phenotypic variability and demonstrated that they can be successfully modulated by pharmacological agents. A potential role is suggested in the treatment of conditions such as ischemic stroke and cognitive disorders.

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Year:  2001        PMID： 11496927     DOI： 10.1177/107385840100700211

Source DB:  PubMed          Journal:  Neuroscientist        ISSN： 1073-8584            Impact factor:   7.519


  39 in total

1.  Conditional protein phosphorylation regulates BK channel activity in rat cerebellar Purkinje neurons.

Authors:  Hélène A Widmer; Iain C M Rowe; Michael J Shipston
Journal:  J Physiol       Date:  2003-10-15       Impact factor: 5.182

2.  Electrophysiological properties of BK channels in Xenopus motor nerve terminals.

Authors:  Xiao-Ping Sun; Bruce Yazejian; Alan D Grinnell
Journal:  J Physiol       Date:  2004-03-26       Impact factor: 5.182

3.  Functional characterization of large conductance calcium-activated K+ channel openers in bladder and vascular smooth muscle.

Authors:  John Malysz; Steven A Buckner; Anthony V Daza; Ivan Milicic; Arturo Perez-Medrano; Murali Gopalakrishnan
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2004-04-17       Impact factor: 3.000

4.  Differential regulation of calcium-activated potassium channels by dynamic intracellular calcium signals.

Authors:  Joanne E Millership; Caroline Heard; Ian M Fearon; Jason I E Bruce
Journal:  J Membr Biol       Date:  2010-06-11       Impact factor: 1.843

5.  Functional contribution of the endothelial component to the vasorelaxing effect of resveratrol and NS 1619, activators of the large-conductance calcium-activated potassium channels.

Authors:  Vincenzo Calderone; Alma Martelli; Lara Testai; Enrica Martinotti; Maria C Breschi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2007-01-04       Impact factor: 3.000

6.  Modes of operation of the BKCa channel beta2 subunit.

Authors:  Nicoletta Savalli; Andrei Kondratiev; Sarah Buxton de Quintana; Ligia Toro; Riccardo Olcese
Journal:  J Gen Physiol       Date:  2007-07       Impact factor: 4.086

7.  The RCK2 domain of the human BKCa channel is a calcium sensor.

Authors:  Taleh Yusifov; Nicoletta Savalli; Chris S Gandhi; Michela Ottolia; Riccardo Olcese
Journal:  Proc Natl Acad Sci U S A       Date:  2007-12-27       Impact factor: 11.205

Review 8.  Calcium-activated potassium channels and endothelial dysfunction: therapeutic options?

Authors:  Michel Félétou
Journal:  Br J Pharmacol       Date:  2009-01-29       Impact factor: 8.739

9.  Ca2+- and thromboxane-dependent distribution of MaxiK channels in cultured astrocytes: from microtubules to the plasma membrane.

Authors:  J W Ou; Y Kumar; A Alioua; C Sailer; E Stefani; L Toro
Journal:  Glia       Date:  2009-09       Impact factor: 7.452

10.  Identification of a BK channel auxiliary protein controlling molecular and behavioral tolerance to alcohol.

Authors:  Gilles E Martin; Linzy M Hendrickson; Krista L Penta; Ryan M Friesen; Andrzej Z Pietrzykowski; Andrew R Tapper; Steven N Treistman
Journal:  Proc Natl Acad Sci U S A       Date:  2008-11-03       Impact factor: 11.205
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