Literature DB >> 11496142

Responses of rat dorsal column neurons to pancreatic nociceptive stimulation.

C C Wang1, K N Westlund.   

Abstract

Our previous study has shown that the postsynaptic dorsal column pathway is involved in transmission of pancreatic nociceptive information from the spinal cord to the thalamus. The aim of the present study was to characterize the neuronal responses in the dorsal column nuclei of the rat to pancreatic nociceptive stimulation. Brief application of bradykinin (10 microg/ml, 20s) to the surface of the pancreas resulted in a significantly increased firing rate in approximately 10% of neurons recorded. In conclusion, pancreatic nociceptive information relayed to the dorsal column nuclei is transmitted from the spinal cord through the dorsal columns.

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Year:  2001        PMID： 11496142     DOI： 10.1097/00001756-200108080-00047

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  8 in total

1.  Upper thoracic postsynaptic dorsal column neurons conduct cardiac mechanoreceptive information, but not cardiac chemical nociception in rats.

Authors:  Melanie D Goodman-Keiser; Chao Qin; Ann M Thompson; Robert D Foreman
Journal:  Brain Res       Date:  2010-11-03       Impact factor: 3.252

2.  Central lateral thalamic neurons receive noxious visceral mechanical and chemical input in rats.

Authors:  Yong Ren; Liping Zhang; Ying Lu; Hong Yang; Karin N Westlund
Journal:  J Neurophysiol       Date:  2009-04-15       Impact factor: 2.714

3.  Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer.

Authors:  Jami L Saloman; Kathryn M Albers; Dongjun Li; Douglas J Hartman; Howard C Crawford; Emily A Muha; Andrew D Rhim; Brian M Davis
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-29       Impact factor: 11.205

Review 4.  Role of neurogenic inflammation in pancreatitis and pancreatic pain.

Authors:  Louis Vera-Portocarrero; Karin N Westlund
Journal:  Neurosignals       Date:  2005

5.  Endogenous opioids inhibit early-stage pancreatic pain in a mouse model of pancreatic cancer.

Authors:  Molly A Sevcik; Beth M Jonas; Theodore H Lindsay; Kyle G Halvorson; Joseph R Ghilardi; Michael A Kuskowski; Pinku Mukherjee; John E Maggio; Patrick W Mantyh
Journal:  Gastroenterology       Date:  2006-09       Impact factor: 22.682

6.  Intrathecal gabapentin enhances the analgesic effects of subtherapeutic dose morphine in a rat experimental pancreatitis model.

Authors:  Matthew M Smiley; Ying Lu; Louis P Vera-Portocarrero; Amr Zidan; Karin N Westlund
Journal:  Anesthesiology       Date:  2004-09       Impact factor: 7.892

7.  fMRI of supraspinal areas after morphine and one week pancreatic inflammation in rats.

Authors:  Karin N Westlund; Louis P Vera-Portocarrero; Liping Zhang; Jingna Wei; Michael J Quast; Charles S Cleeland
Journal:  Neuroimage       Date:  2008-08-05       Impact factor: 6.556

Review 8.  Effects of general anesthetics on visceral pain transmission in the spinal cord.

Authors:  Yun Wang; Jing Wu; Qing Lin; Hj Nauta; Yun Yue; Li Fang
Journal:  Mol Pain       Date:  2008-10-30       Impact factor: 3.395
  8 in total

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