Literature DB >> 11496101

Basal expression of bradykinin B(1) receptor in the spinal cord in humans and rats.

Q P Ma1, R Heavens.   

Abstract

The bradykinin B(1) receptor has been considered as a receptor induced by tissue injury and inflammation mainly in the peripheral tissues. In the present study, we have investigated whether there is a basal expression in the spinal cord by both reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemical staining methods. Southern blotting of the DNA reverse-transcribed from human and rat spinal cord mRNA and amplified by polymerase chain reaction (PCR) showed a substantial basal B(1) receptor expression in both human and rat spinal cord. Immunohistochemical staining demonstrated B(1)-positive neurons in the spinal cord dorsal horn, suggesting that the B(1) receptor is constitutively expressed by spinal neurons.

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Year:  2001        PMID： 11496101     DOI： 10.1097/00001756-200108080-00006

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  8 in total

Review 1.  Kinin B1 receptors: key G-protein-coupled receptors and their role in inflammatory and painful processes.

Authors:  João B Calixto; Rodrigo Medeiros; Elizabeth S Fernandes; Juliano Ferreira; Daniela A Cabrini; Maria M Campos
Journal:  Br J Pharmacol       Date:  2004-11-01       Impact factor: 8.739

2.  Anti-nociceptive effect of kinin B₁ and B₂ receptor antagonists on peripheral neuropathy induced by paclitaxel in mice.

Authors:  Robson Costa; Emerson M Motta; Rafael C Dutra; Marianne N Manjavachi; Allisson F Bento; Fernanda R Malinsky; João B Pesquero; João B Calixto
Journal:  Br J Pharmacol       Date:  2011-09       Impact factor: 8.739

3.  Kinin B1 receptors contributes to acute pain following minor surgery in humans.

Authors:  May Hamza; Xiao-Min Wang; Albert Adam; Jaime S Brahim; Janet S Rowan; Gilberto N Carmona; Raymond A Dionne
Journal:  Mol Pain       Date:  2010-02-13       Impact factor: 3.395

4.  The role of kinin B1 and B2 receptors in the scratching behaviour induced by proteinase-activated receptor-2 agonists in mice.

Authors:  Robson Costa; Marianne N Manjavachi; Emerson M Motta; Denise M Marotta; Luiz Juliano; Hugo A Torres; João B Pesquero; João B Calixto
Journal:  Br J Pharmacol       Date:  2010-01-08       Impact factor: 8.739

5.  Effects of kinin B(1) and B(2) receptor antagonists on overactive urinary bladder syndrome induced by spinal cord injury in rats.

Authors:  Stefânia Forner; Edinéia L Andrade; Alessandra C Martini; Allisson F Bento; Rodrigo Medeiros; Janice Koepp; João B Calixto
Journal:  Br J Pharmacol       Date:  2012-12       Impact factor: 8.739

Review 6.  Differential regulation of inducible and endothelial nitric oxide synthase by kinin B1 and B2 receptors.

Authors:  F Kuhr; J Lowry; Y Zhang; V Brovkovych; R A Skidgel
Journal:  Neuropeptides       Date:  2010-01-04       Impact factor: 3.286

7.  Activation of the Kinin B1 Receptor by Its Agonist Reduces Melanoma Metastasis by Playing a Dual Effect on Tumor Cells and Host Immune Response.

Authors:  Andrea Gutierrez Maria; Patrícia Dillemburg-Pilla; Marina de Toledo Durand; Elaine Medeiros Floriano; Adriana Oliveira Manfiolli; Simone Gusmão Ramos; João Bosco Pesquero; Clara Nahmias; Claudio M Costa-Neto
Journal:  Front Pharmacol       Date:  2019-09-25       Impact factor: 5.810

8.  Cellular localization of kinin B1 receptor in the spinal cord of streptozotocin-diabetic rats with a fluorescent [Nalpha-Bodipy]-des-Arg9-bradykinin.

Authors:  Sébastien Talbot; Patrick Théberge-Turmel; Dalinda Liazoghli; Jacques Sénécal; Pierrette Gaudreau; Réjean Couture
Journal:  J Neuroinflammation       Date:  2009-03-26       Impact factor: 8.322
  8 in total

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