Literature DB >> 11495802

Trypanosome lytic factors: novel mediators of human innate immunity.

J Raper1, M P Portela, E Lugli, U Frevert, S Tomlinson.   

Abstract

A novel trypanosome lytic factor (TLF) has been characterized that protects humans from infection by Trypanosoma brucei brucei. The mechanism of trypanolysis is unknown; contrary to one hypothesis, TLF does not kill trypanosomes by generating oxygen radicals. However, these trypanosomes become human-infective when they express a serum-resistance-associated gene.

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Year:  2001        PMID： 11495802     DOI： 10.1016/s1369-5274(00)00226-5

Source DB:  PubMed          Journal:  Curr Opin Microbiol        ISSN： 1369-5274            Impact factor:   7.934


  20 in total

1.  Rab28 function in trypanosomes: interactions with retromer and ESCRT pathways.

Authors:  Jennifer H Lumb; Ka Fai Leung; Kelly N Dubois; Mark C Field
Journal:  J Cell Sci       Date:  2011-11-18       Impact factor: 5.285

2.  Biological variation among african trypanosomes: I. Clonal expression of virulence is not linked to the variant surface glycoprotein or the variant surface glycoprotein gene telomeric expression site.

Authors:  Jill A Inverso; Timothy S Uphoff; Scott C Johnson; Donna M Paulnock; John M Mansfield
Journal:  DNA Cell Biol       Date:  2010-05       Impact factor: 3.311

Review 3.  Microbial pathogenesis: mechanisms of infectious disease.

Authors:  Vern B Carruthers; Peggy A Cotter; Carol A Kumamoto
Journal:  Cell Host Microbe       Date:  2007-10-11       Impact factor: 21.023

4.  In vitro generation of human high-density-lipoprotein-resistant Trypanosoma brucei brucei.

Authors:  Sara D Faulkner; Monika W Oli; Rudo Kieft; Laura Cotlin; Justin Widener; April Shiflett; Michael J Cipriano; Sarah E Pacocha; Shanda R Birkeland; Stephen L Hajduk; Andrew G McArthur
Journal:  Eukaryot Cell       Date:  2006-08

5.  The Scl1 of M41-type group A Streptococcus binds the high-density lipoprotein.

Authors:  Yumin Gao; Chunwei Liang; Ruidong Zhao; Slawomir Lukomski; Runlin Han
Journal:  FEMS Microbiol Lett       Date:  2010-05-14       Impact factor: 2.742

6.  Human trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers: relevance to trypanosome lysis.

Authors:  Russell Thomson; Alan Finkelstein
Journal:  Proc Natl Acad Sci U S A       Date:  2015-02-17       Impact factor: 11.205

7.  Serum resistance-associated protein blocks lysosomal targeting of trypanosome lytic factor in Trypanosoma brucei.

Authors:  Monika W Oli; Laura F Cotlin; April M Shiflett; Stephen L Hajduk
Journal:  Eukaryot Cell       Date:  2006-01

8.  Trypanosome Lytic Factor-1 Initiates Oxidation-stimulated Osmotic Lysis of Trypanosoma brucei brucei.

Authors:  Amy Styer Greene; Stephen L Hajduk
Journal:  J Biol Chem       Date:  2015-12-08       Impact factor: 5.157

Review 9.  Activity of trypanosome lytic factor: a novel component of innate immunity.

Authors:  Russell Thomson; Marie Samanovic; Jayne Raper
Journal:  Future Microbiol       Date:  2009-09       Impact factor: 3.165

10.  A single amino acid substitution in the group 1 Trypanosoma brucei gambiense haptoglobin-hemoglobin receptor abolishes TLF-1 binding.

Authors:  E DeJesus; R Kieft; B Albright; N A Stephens; S L Hajduk
Journal:  PLoS Pathog       Date:  2013-04-18       Impact factor: 6.823
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