Literature DB >> 11495482

Effect of particle inlet distributions on deposition in a triple bifurcation lung airway model.

Z Zhang1, C Kleinstreuer.   

Abstract

Considering a triple bifurcation as a representative lung airway model of the upper bronchial tree, the effect of different random inlet particle distributions on deposition patterns and efficiencies have been numerically analyzed. The steady laminar three-dimensional transport equations for a dilute micron-size particle suspension have been solved using a commercial finite-volume code with user-enhanced programs. Particle release positions were assigned employing a random number generator following random-parabolic, random-uniform, and random-random distribution functions. Via back tracking, starting positions of all depositing particles were determined for each particle release distribution, including a deterministic-parabolic one which served as a base case. The results indicate that: (1) The starting regions of the depositing particles in a given bifurcation are fixed for the same inlet Reynolds number and Stokes number combination, regardless of the type of distribution profile. The situation for the particle deposition patterns is somewhat similar. However, the type of distribution of inlet particles strongly influences the particle deposition efficiencies. (2) Values of particle deposition efficiencies are very close for the same (parabolically) distributed deterministic versus random inlet particles when all other conditions are fixed. (3) According to the simulation validations, a determinstic parabolic distribution of inlet particles may be sufficient for laboratory data comparison purposes, but random distributions should reflect realistic environmental or medical aerosol inhalation more accurately.

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Year:  2001        PMID: 11495482     DOI: 10.1089/08942680152007864

Source DB:  PubMed          Journal:  J Aerosol Med        ISSN: 0894-2684


  6 in total

1.  Distribution of aerosolized particles in healthy and emphysematous rat lungs: comparison between experimental and numerical studies.

Authors:  Jessica M Oakes; Alison L Marsden; Céline Grandmont; Chantal Darquenne; Irene E Vignon-Clementel
Journal:  J Biomech       Date:  2015-01-22       Impact factor: 2.712

Review 2.  In silico models of aerosol delivery to the respiratory tract - development and applications.

Authors:  P Worth Longest; Landon T Holbrook
Journal:  Adv Drug Deliv Rev       Date:  2011-05-27       Impact factor: 15.470

3.  CFD simulations of enhanced condensational growth (ECG) applied to respiratory drug delivery with comparisons to in vitro data.

Authors:  P Worth Longest; Michael Hindle
Journal:  J Aerosol Sci       Date:  2010-08-01       Impact factor: 3.433

Review 4.  Multiscale image-based modeling and simulation of gas flow and particle transport in the human lungs.

Authors:  Ching-Long Lin; Merryn H Tawhai; Eric A Hoffman
Journal:  Wiley Interdiscip Rev Syst Biol Med       Date:  2013-07-10

5.  A combined experimental and numerical study on upper airway dosimetry of inhaled nanoparticles from an electrical discharge machine shop.

Authors:  Lin Tian; Yidan Shang; Rui Chen; Ru Bai; Chunying Chen; Kiao Inthavong; Jiyuan Tu
Journal:  Part Fibre Toxicol       Date:  2017-07-12       Impact factor: 9.400

Review 6.  A Review of Respiratory Anatomical Development, Air Flow Characterization and Particle Deposition.

Authors:  Mohammad S Islam; Gunther Paul; Hui X Ong; Paul M Young; Y T Gu; Suvash C Saha
Journal:  Int J Environ Res Public Health       Date:  2020-01-07       Impact factor: 3.390

  6 in total

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