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Literature DB >> 11494111

Poly(ADP-ribosyl)ation of p53 in vitro and in vivo modulates binding to its DNA consensus sequence.

C M Simbulan-Rosenthal¹, D S Rosenthal, R B Luo, R Samara, M Jung, A Dritschilo, A Spoonde, M E Smulson.

Abstract

The tumor-suppressor p53 undergoes extensive poly(ADP-ribosyl)ation early during apoptosis in human osteosarcoma cells, and degradation of poly(ADP-ribose) (PAR) attached to p53 coincides with poly(ADP-ribose)polymerase-1, (PARP-1) cleavage, and expression of p53 target genes. The mechanism by which poly(ADP-ribosyl)ation may regulate p53 function has now been investigated. Purified wild-type PARP-1 catalyzed the poly(ADP-ribosyl) of full-length p53 in vitro. In gel supershift assays, poly(ADP-ribosyl)ation suppressed p53 binding to its DNA consensus sequence; however, when p53 remained unmodified in the presence of inactive mutant PARP-1, it retained sequence-specific DNA binding activity. Poly(ADP-ribosyl)ation of p53 by PARP-1 during early apoptosis in osteosarcoma cells also inhibited p53 interaction with its DNA consensus sequence; thus, poly(ADP-ribosyl)ation may represent a novel means for regulating transcriptional activation by p53 in vivo.

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Year: 2001 PMID： 11494111 PMCID： PMC1505598 DOI： 10.1038/sj.neo.7900155

Source DB: PubMed Journal: Neoplasia ISSN： 1476-5586 Impact factor: 5.715

69 in total

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Authors: Y Desmarais; L Ménard; J Lagueux; G G Poirier
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2. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.

Authors: H Vaziri; M D West; R C Allsopp; T S Davison; Y S Wu; C H Arrowsmith; G G Poirier; S Benchimol
Journal: EMBO J Date: 1997-10-01 Impact factor: 11.598

3. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain.

Authors: W Gu; R G Roeder
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4. Poly(ADP-ribose)-mediated post-translational modification of chromatin-associated human topoisomerase I. Inhibitory effects on catalytic activity.

Authors: U N Kasid; B Halligan; L F Liu; A Dritschilo; M Smulson
Journal: J Biol Chem Date: 1989-11-05 Impact factor: 5.157

5. Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions.

Authors: M Malanga; J M Pleschke; H E Kleczkowska; F R Althaus
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Authors: A Tanizawa; M Kubota; H Hashimoto; T Shimizu; T Takimoto; T Kitoh; Y Akiyama; H Mikawa
Journal: Exp Cell Res Date: 1989-11 Impact factor: 3.905

7. TFIIF, a basal eukaryotic transcription factor, is a substrate for poly(ADP-ribosyl)ation.

Authors: J M Rawling; R Alvarez-Gonzalez
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9. Isolation and characterization of the cDNA encoding bovine poly(ADP-ribose) glycohydrolase.

Authors: W Lin; J C Amé; N Aboul-Ela; E L Jacobson; M K Jacobson
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10. Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA.

Authors: J Ménissier-de Murcia; M Molinete; G Gradwohl; F Simonin; G de Murcia
Journal: J Mol Biol Date: 1989-11-05 Impact factor: 5.469

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