Literature DB >> 1149128

The effect of tetrabenazine on the accumulation of noradrenaline in constricted postganglionic sympathetic nerves in vitro.

D R Tomlinson, R J Till, D Mayor.   

Abstract

The accumulation of noradrenaline proximal to a constriction applied to cat hypogastric nerves in vitro has been studied in preparations treated with tetrabenazine. The accumulation of amine was almost completely abolished by the drug. Evidence is presented which suggests that tetrabenazine exerts a direct noradrenaline-depleting effect on the intraneuronal storage vesicles. Recovery of noradrenaline levels after the removal of the drug was rapid and was effected by the biosynthesis of new noradrenaline within the axon.

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Year:  1975        PMID： 1149128     DOI： 10.1007/bf00225766

Source DB:  PubMed          Journal:  Cell Tissue Res        ISSN： 0302-766X            Impact factor:   5.249


  14 in total

1.  AN IMPROVED METHOD FOR FLUORIMETRIC DETERMINATION OF SMALL AMOUNTS OF ADRENALINE AND NORADRENALINE IN PLASMA AND TISSUES.

Authors:  J HAEGGENDAL
Journal:  Acta Physiol Scand       Date:  1963-11

2.  Two populations or granular vesicles in constricted post-ganglionic sympathetic nerves.

Authors:  D R Tomlinson
Journal:  J Physiol       Date:  1975-03       Impact factor: 5.182

3.  The effects of drugs on noradrenaline and dense-cored vesicles in ligated post-ganglionic sympathetic nerves in vitro.

Authors:  P Banks; D Mayor; D R Tomlinson
Journal:  J Physiol       Date:  1972-04       Impact factor: 5.182

4.  Recovery of noradrenaline in adrenergic axons of rat sciatic nerves after reserpine treatment.

Authors:  A Dahlström; J Häggendal
Journal:  J Pharm Pharmacol       Date:  1969-10       Impact factor: 3.765

5.  Acrylic aldehyde in sodium dichromate as a fixative for identifying catecholamine storage sites with the electron microscope.

Authors:  R I Woods
Journal:  J Physiol       Date:  1969-07       Impact factor: 5.182

6.  The effects of iproniazid and reserpine on the accumulation of granular vesicles and noradrenaline in constricted adrenergic nerves.

Authors:  P Banks; K Kapeller; D Mayor
Journal:  Br J Pharmacol       Date:  1969-09       Impact factor: 8.739

7.  Histochemical and functional relationships of catecholamines in adrenergic nerve endings. I. Participation of granular vesicles.

Authors:  L S Van Orden; F E Bloom; R J Barnett; N J Giarman
Journal:  J Pharmacol Exp Ther       Date:  1966-11       Impact factor: 4.030

8.  Observations on the accumulation of noradrenaline in the proximal and distal parts of peripheral adrenergic nerves after compression.

Authors:  A Dahlström
Journal:  J Anat       Date:  1965-10       Impact factor: 2.610

9.  Studies on the translocation of noradrenaline-containing vesicles in post-ganglionic sympathetic neurones in vitro. Inhibition of movement by colchicine and vinblastine and evidence for the involvement of axonal microtubules.

Authors:  P Banks; D Mayor; M Mitchell; D Tomlinson
Journal:  J Physiol       Date:  1971-08       Impact factor: 5.182

10.  The use of lead citrate at high pH as an electron-opaque stain in electron microscopy.

Authors:  E S REYNOLDS
Journal:  J Cell Biol       Date:  1963-04       Impact factor: 10.539
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  1 in total

1.  The mode of action of tetrabenazine on peripheral noradrenergic nerves.

Authors:  D R Tomlinson
Journal:  Br J Pharmacol       Date:  1977-11       Impact factor: 8.739
  1 in total

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