Literature DB >> 11490092

Nerve growth factor and striatal glutathione metabolism in a rat model of Huntington's disease.

Reyniel Cruz-Aguado1, Liliana Francis Turner, Carmen M. Díaz, Janet Piñero.   

Abstract

Purpose: To test the influence of nerve growth factor (NGF) on striatal glutathione (GSH) content and the activities of GSH-related enzymes from quinolinic acid-lesioned rats.
Methods: Rats were intrastriatally injected with QA and NGF. Enzymatic and GSH assays were performed one week later.
Results: NGF prevented the QA-induced decline in glutathione reductase activity and GSH content. Conclusions: NGF is able to prevent some of the disturbances induced by the excitotoxic insult in the striatal GSH metabolism.

Entities:  

Year:  2000        PMID： 11490092

Source DB:  PubMed          Journal:  Restor Neurol Neurosci        ISSN： 0922-6028            Impact factor:   2.406


  2 in total

Review 1.  Targeting the Cholinergic System to Develop a Novel Therapy for Huntington's Disease.

Authors:  Gary X D'Souza; Henry J Waldvogel
Journal:  J Huntingtons Dis       Date:  2016-12-15

2.  Systemic L-Buthionine -S-R-Sulfoximine Treatment Increases Plasma NGF and Upregulates L-cys/L-cys2 Transporter and γ-Glutamylcysteine Ligase mRNAs Through the NGF/TrkA/Akt/Nrf2 Pathway in the Striatum.

Authors:  Cesar Valdovinos-Flores; Jorge H Limón-Pacheco; Renato León-Rodríguez; Pavel Petrosyan; Carla Garza-Lombó; Maria E Gonsebatt
Journal:  Front Cell Neurosci       Date:  2019-07-23       Impact factor: 5.505
  2 in total

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