| Literature DB >> 11489980 |
M Kruse1, E Meinl, G Henning, C Kuhnt, S Berchtold, T Berger, G Schuler, A Steinkasserer.
Abstract
Signaling lymphocyte activation molecule (SLAM), a 70-kDa costimulatory molecule that mediates CD28-independent proliferation of T cells and IFN-gamma production, has been identified on human T cells, immature thymocytes, and a subset of B cells. We have found that SLAM is expressed on mature but not immature dendritic cells (DC). However, the SLAM-associated protein, is missing in DC. SLAM surface expression is strongly up-regulated by IL-1beta. Addition of IL-1beta to the DC maturation mixture also increases the stimulatory properties of DC. These findings provide a new marker for DC maturation and help to explain two areas of DC biology. First, SLAM is a receptor for the measles virus, previously shown to infect DC. Second, SLAM could possibly contribute to the enhanced immunostimulatory functions of DC that are observed following the addition of IL-1.Entities:
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Year: 2001 PMID： 11489980 DOI： 10.4049/jimmunol.167.4.1989
Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422