Literature DB >> 11489465

Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors.

C A Brady1, I M Stanford, I Ali, L Lin, J M Williams, A E Dubin, A G Hope, N M Barnes.   

Abstract

The present study determined the detailed pharmacological profile of heterologously expressed human (h) homomeric 5-HT3A receptors in direct comparison to heteromeric h5-HT3A/3B receptors. The very minor differences in their respective pharmacological profiles indicates that the 5-HT3B receptor subunit alters, predominantly, the biophysical rather than the pharmacological properties of the 5-HT3 receptor.

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Year:  2001        PMID： 11489465     DOI： 10.1016/s0028-3908(01)00074-0

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  27 in total

1.  VUF10166, a novel compound with differing activities at 5-HT₃A and 5-HT₃AB receptors.

Authors:  A J Thompson; M H P Verheij; I J P de Esch; S C R Lummis
Journal:  J Pharmacol Exp Ther       Date:  2012-02-03       Impact factor: 4.030

2.  5-HT3 receptor antagonists ameliorate fatigue: so much potential, so little knowledge!

Authors:  N M Barnes
Journal:  Gut       Date:  2005-08       Impact factor: 23.059

3.  Mapping spatial relationships between residues in the ligand-binding domain of the 5-HT3 receptor using a molecular ruler.

Authors:  Heather L Nyce; Spencer T Stober; Cameron F Abrams; Michael M White
Journal:  Biophys J       Date:  2010-05-19       Impact factor: 4.033

4.  Cysteine modification reveals which subunits form the ligand binding site in human heteromeric 5-HT3AB receptors.

Authors:  A J Thompson; K L Price; S C R Lummis
Journal:  J Physiol       Date:  2011-06-27       Impact factor: 5.182

Review 5.  The 5-HT3 receptor as a therapeutic target.

Authors:  Andrew J Thompson; Sarah C R Lummis
Journal:  Expert Opin Ther Targets       Date:  2007-04       Impact factor: 6.902

Review 6.  5-HT3 receptors.

Authors:  A J Thompson; S C R Lummis
Journal:  Curr Pharm Des       Date:  2006       Impact factor: 3.116

7.  From mouse to man: the 5-HT3 receptor modulates physical dependence on opioid narcotics.

Authors:  Larry F Chu; De-Yong Liang; Xiangqi Li; Peyman Sahbaie; Nicole D'arcy; Guochun Liao; Gary Peltz; J David Clark
Journal:  Pharmacogenet Genomics       Date:  2009-03       Impact factor: 2.089

Review 8.  Novel structural determinants of single channel conductance and ion selectivity in 5-hydroxytryptamine type 3 and nicotinic acetylcholine receptors.

Authors:  John A Peters; Michelle A Cooper; Jane E Carland; Matthew R Livesey; Tim G Hales; Jeremy J Lambert
Journal:  J Physiol       Date:  2009-11-23       Impact factor: 5.182

9.  5-Chloroindole: a potent allosteric modulator of the 5-HT₃ receptor.

Authors:  Amy S Newman; Nikolaos Batis; Gillian Grafton; Francesca Caputo; Catherine A Brady; Jeremy J Lambert; John A Peters; John Gordon; Keith L Brain; Andrew D Powell; Nicholas M Barnes
Journal:  Br J Pharmacol       Date:  2013-07       Impact factor: 8.739

10.  Novel mechanism of modulation at a ligand-gated ion channel; action of 5-Cl-indole at the 5-HT3 A receptor.

Authors:  Andrew D Powell; Gillian Grafton; Alexander Roberts; Shannon Larkin; Nathanael O'Neill; Josephine Palandri; Reka Otvos; Alison J Cooper; Chris Ulens; Nicholas M Barnes
Journal:  Br J Pharmacol       Date:  2016-11-01       Impact factor: 8.739
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