Literature DB >> 11489449

Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats.

V L Rao1, A Dogan, K G Todd, K K Bowen, R J Dempsey.   

Abstract

This study investigated whether memantine, a non-competitive NMDA receptor antagonist is neuroprotective after traumatic brain injury (TBI) induced in adult rats with a controlled cortical impact device. TBI led to significant neuronal death in the hippocampal CA2 and CA3 regions (by 50 and 59%, respectively), by 7 days after the injury. Treatment of rats with memantine (10 and 20 mg/Kg, i.p.) immediately after the injury significantly prevented the neuronal loss in both CA2 and CA3 regions. This is the first study showing the neuroprotective potential of memantine to prevent the TBI-induced neuronal damage.

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Year:  2001        PMID： 11489449     DOI： 10.1016/s0006-8993(01)02617-8

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  32 in total

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2.  N-methyl-D-aspartate receptor mechanosensitivity is governed by C terminus of NR2B subunit.

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3.  Mild traumatic brain injury-induced hippocampal gene expressions: The identification of target cellular processes for drug development.

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Journal:  J Neurosci Methods       Date:  2016-02-08       Impact factor: 2.390

Review 4.  Preconditioning provides neuroprotection in models of CNS disease: paradigms and clinical significance.

Authors:  R Anne Stetler; Rehana K Leak; Yu Gan; Peiying Li; Feng Zhang; Xiaoming Hu; Zheng Jing; Jun Chen; Michael J Zigmond; Yanqin Gao
Journal:  Prog Neurobiol       Date:  2014-01-02       Impact factor: 11.685

Review 5.  Therapeutic strategies to target acute and long-term sequelae of pediatric traumatic brain injury.

Authors:  Jimmy W Huh; Ramesh Raghupathi
Journal:  Neuropharmacology       Date:  2018-06-20       Impact factor: 5.250

6.  The effects of a single memantine treatment on behavioral alterations associated with binge alcohol exposure in neonatal rats.

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Review 7.  Glutamate and neurotrophic factors in neuronal plasticity and disease.

Authors:  Mark P Mattson
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8.  Glutamate-Mediated Blood-Brain Barrier Opening: Implications for Neuroprotection and Drug Delivery.

Authors:  Udi Vazana; Ronel Veksler; Gaby S Pell; Ofer Prager; Michael Fassler; Yoash Chassidim; Yiftach Roth; Hamutal Shahar; Abraham Zangen; Ruggero Raccah; Emanuela Onesti; Marco Ceccanti; Claudio Colonnese; Antonio Santoro; Maurizio Salvati; Alessandro D'Elia; Valter Nucciarelli; Maurizio Inghilleri; Alon Friedman
Journal:  J Neurosci       Date:  2016-07-20       Impact factor: 6.167

9.  Pharmacodynamics of memantine: an update.

Authors:  G Rammes; W Danysz; C G Parsons
Journal:  Curr Neuropharmacol       Date:  2008-03       Impact factor: 7.363

Review 10.  Memantine: a review of studies into its safety and efficacy in treating Alzheimer's disease and other dementias.

Authors:  Stuart J Thomas; George T Grossberg
Journal:  Clin Interv Aging       Date:  2009-10-12       Impact factor: 4.458
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