Literature DB >> 11489425

Drug resistance in Trypanosoma brucei spp., the causative agents of sleeping sickness in man and nagana in cattle.

E Matovu1, T Seebeck, J C Enyaru, R Kaminsky.   

Abstract

Drug resistance in pathogenic trypanosomes threatens successful control of fatal sleeping sickness in man and hinders economic livestock production in sub-Saharan Africa. We report on the occurrence and development of drug resistance, and discuss the genetic basis of such resistance in Trypanosoma brucei. Understanding these mechanisms at the molecular level will enable improved management of existing drugs and provide valuable clues to the development of new trypanocides.

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Year:  2001        PMID： 11489425     DOI： 10.1016/s1286-4579(01)01432-0

Source DB:  PubMed          Journal:  Microbes Infect        ISSN： 1286-4579            Impact factor:   2.700


  37 in total

1.  Trypanocidal activities of trileucine methyl vinyl sulfone proteasome inhibitors.

Authors:  Dietmar Steverding; Robert W Spackman; Howard J Royle; Robert J Glenn
Journal:  Parasitol Res       Date:  2004-12-01       Impact factor: 2.289

2.  Trypanosoma brucei RNA binding proteins p34 and p37 mediate NOPP44/46 cellular localization via the exportin 1 nuclear export pathway.

Authors:  Kristina Hellman; Kimberly Prohaska; Noreen Williams
Journal:  Eukaryot Cell       Date:  2007-10-05

3.  Synthesis and evaluation of human phosphodiesterases (PDE) 5 inhibitor analogs as trypanosomal PDE inhibitors. Part 2. Tadalafil analogs.

Authors:  Stefan O Ochiana; Alden Gustafson; Nicholas D Bland; Cuihua Wang; Michael J Russo; Robert K Campbell; Michael P Pollastri
Journal:  Bioorg Med Chem Lett       Date:  2012-02-09       Impact factor: 2.823

4.  The trypanocidal effect of NO-releasing agents is not due to inhibition of the major cysteine proteinase in Trypanosoma brucei.

Authors:  Dietmar Steverding; Xia Wang; Darren W Sexton
Journal:  Parasitol Res       Date:  2009-07-16       Impact factor: 2.289

5.  Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.

Authors:  Enock Matovu; Mhairi L Stewart; Federico Geiser; Reto Brun; Pascal Mäser; Lynsey J M Wallace; Richard J Burchmore; John C K Enyaru; Michael P Barrett; Ronald Kaminsky; Thomas Seebeck; Harry P de Koning
Journal:  Eukaryot Cell       Date:  2003-10

6.  The trypanocide diminazene aceturate is accumulated predominantly through the TbAT1 purine transporter: additional insights on diamidine resistance in african trypanosomes.

Authors:  Harry P de Koning; Laura F Anderson; Mhairi Stewart; Richard J S Burchmore; Lynsey J M Wallace; Michael P Barrett
Journal:  Antimicrob Agents Chemother       Date:  2004-05       Impact factor: 5.191

7.  An expression system to screen for inhibitors of parasite glucose transporters.

Authors:  Torben Feistel; Cheryl A Hodson; David H Peyton; Scott M Landfear
Journal:  Mol Biochem Parasitol       Date:  2008-07-30       Impact factor: 1.759

Review 8.  Revisiting zoonotic human African trypanosomiasis control in Uganda.

Authors:  Sonia Menon; Rodolfo Rossi; Leon Nshimyumukiza; Kate Zinszer
Journal:  J Public Health Policy       Date:  2015-12-03       Impact factor: 2.222

9.  Excreted/secreted proteins from trypanosome procyclic strains.

Authors:  Celestine Michelle Atyame Nten; Nicolas Sommerer; Valerie Rofidal; Christophe Hirtz; Michel Rossignol; Gerard Cuny; Jean-Benoit Peltier; Anne Geiger
Journal:  J Biomed Biotechnol       Date:  2010

10.  Trypanocidal activity of the proteasome inhibitor and anti-cancer drug bortezomib.

Authors:  Dietmar Steverding; Xia Wang
Journal:  Parasit Vectors       Date:  2009-07-07       Impact factor: 3.876
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