Literature DB >> 11489270

Post-ischemic hypothermia blocks caspase-3 activation in the newborn rat brain after hypoxia-ischemia.

H Fukuda1, T Tomimatsu, N Watanabe, J W Mu, M Kohzuki, M Endo, E Fujii, T Kanzaki, Y Murata.   

Abstract

The effects of hypothermia on caspase-3 activation were investigated in the newborn rat brain after hypoxia-ischemia (HI). Intense caspase-3 activation was observed in the control brains after HI, but this activation was significantly reduced by postischemic hypothermia. These findings suggest that the inhibition of caspase-3 activation may be an interventional point underlying the neuroprotective effect of hypothermia in neonates.

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Year:  2001        PMID： 11489270     DOI： 10.1016/s0006-8993(01)02659-2

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  11 in total

1.  Hypothermia for hypoxic-ischemic encephalopathy.

Authors:  C Michael Cotten; Seetha Shankaran
Journal:  Expert Rev Obstet Gynecol       Date:  2010-03-01

Review 2.  The Brain and Hypothermia-From Aristotle to Targeted Temperature Management.

Authors:  Patrick M Kochanek; Travis C Jackson
Journal:  Crit Care Med       Date:  2017-02       Impact factor: 7.598

Review 3.  Global cerebral ischemia due to circulatory arrest: insights into cellular pathophysiology and diagnostic modalities.

Authors:  Santosh K Sanganalmath; Purva Gopal; John R Parker; Richard K Downs; Joseph C Parker; Buddhadeb Dawn
Journal:  Mol Cell Biochem       Date:  2016-11-28       Impact factor: 3.396

Review 4.  Hypothermic neuroprotection against acute ischemic stroke: The 2019 update.

Authors:  Longfei Wu; Di Wu; Tuo Yang; Jin Xu; Jian Chen; Luling Wang; Shuaili Xu; Wenbo Zhao; Chuanjie Wu; Xunming Ji
Journal:  J Cereb Blood Flow Metab       Date:  2019-12-19       Impact factor: 6.200

5.  Elevated temperature after hypoxic-ischemic encephalopathy: risk factor for adverse outcomes.

Authors:  Abbot Laptook; Jon Tyson; Seetha Shankaran; Scott McDonald; Richard Ehrenkranz; Avroy Fanaroff; Edward Donovan; Ronald Goldberg; T Michael O'Shea; Rosemary D Higgins; W Kenneth Poole
Journal:  Pediatrics       Date:  2008-09       Impact factor: 7.124

Review 6.  Therapeutic hypothermia as a neuroprotective strategy in neonatal hypoxic-ischemic brain injury and traumatic brain injury.

Authors:  H Ma; B Sinha; R S Pandya; N Lin; A J Popp; J Li; J Yao; X Wang
Journal:  Curr Mol Med       Date:  2012-12       Impact factor: 2.222

7.  Effect of hypothermia on motor function of adult rats after neonatal hyperthermic hypoxic-ischemic brain insult.

Authors:  Takayoshi Hosono; Ayumi Kamo; Satoshi Hakotani; Kenji Minato; Haruka Akeno; Yu Taguchi; Akiko Miyano; Takumi Iseki
Journal:  Eur J Appl Physiol       Date:  2009-08-14       Impact factor: 3.078

Review 8.  Oxidative stress in angiogenesis and vascular disease.

Authors:  Young-Woong Kim; Tatiana V Byzova
Journal:  Blood       Date:  2013-12-03       Impact factor: 22.113

9.  Extreme prematurity and attention deficit: epidemiology and prevention.

Authors:  T Michael O'Shea; L Corbin Downey; Karl K C Kuban
Journal:  Front Hum Neurosci       Date:  2013-09-19       Impact factor: 3.169

10.  The effect of hypothermia therapy on cortical laminar disruption following ischemic injury in neonatal mice.

Authors:  Hiroyuki Kida; Sadahiro Nomura; Mizuya Shinoyama; Makoto Ideguchi; Yuji Owada; Michiyasu Suzuki
Journal:  PLoS One       Date:  2013-07-23       Impact factor: 3.240
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