Literature DB >> 11489268

Activation of spinal serotonin(2A/2C) receptors augments nociceptive responses in the rat.

A Kjørsvik1, A Tjølsen, K Hole.   

Abstract

The role of spinal 5-HT(2A/2C) receptors in the regulation of spinal nociceptive transmission was studied. The 5-HT(2A/2C) agonist (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and the antagonist ketanserin tartrate were administered intrathecally immediately before the formalin test. Activation of spinal 5-HT(2A/2C) receptors increased the pain-like behavioural response in both the early and late phases. The findings support the hypothesis that spinal 5-HT(2A/2C) receptors augment the spinal afferent nociceptive impulses induced by peripheral inflammation.

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Year:  2001        PMID： 11489268     DOI： 10.1016/s0006-8993(01)02652-x

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

1.  Serotonin receptors are involved in the spinal mediation of descending facilitation of surgical incision-induced increase of Fos-like immunoreactivity in rats.

Authors:  João Walter S Silveira; Quintino M Dias; Elaine A Del Bel; Wiliam A Prado
Journal:  Mol Pain       Date:  2010-03-23       Impact factor: 3.395

2.  Proteome of synaptosome-associated proteins in spinal cord dorsal horn after peripheral nerve injury.

Authors:  Om V Singh; Myron Yaster; Ji-Tian Xu; Yun Guan; Xiaowei Guan; Arun M Dharmarajan; Srinivasa N Raja; Pamela L Zeitlin; Yuan-Xiang Tao
Journal:  Proteomics       Date:  2009-03       Impact factor: 3.984

3.  A pronociceptive role for the 5-HT2 receptor on spinal nociceptive transmission: an in vivo electrophysiological study in the rat.

Authors:  Wahida Rahman; Kirsty Bannister; Lucy A Bee; Anthony H Dickenson
Journal:  Brain Res       Date:  2011-01-26       Impact factor: 3.252

Review 4.  The Role of Descending Pain Modulation in Chronic Primary Pain: Potential Application of Drugs Targeting Serotonergic System.

Authors:  Zhuo-Ying Tao; Pei-Xing Wang; Si-Qi Wei; Richard J Traub; Jin-Feng Li; Dong-Yuan Cao
Journal:  Neural Plast       Date:  2019-12-17       Impact factor: 3.599

Review 5.  Role of Descending Serotonergic Fibers in the Development of Pathophysiology after Spinal Cord Injury (SCI): Contribution to Chronic Pain, Spasticity, and Autonomic Dysreflexia.

Authors:  Gizelle N K Fauss; Kelsey E Hudson; James W Grau
Journal:  Biology (Basel)       Date:  2022-02-01

6.  Identification of 5-HT receptor subtypes enhancing inhibitory transmission in the rat spinal dorsal horn in vitro.

Authors:  Du-Jie Xie; Daisuke Uta; Peng-Yu Feng; Masahito Wakita; Min-Chul Shin; Hidemasa Furue; Megumu Yoshimura
Journal:  Mol Pain       Date:  2012-08-20       Impact factor: 3.395

7.  Mice Lacking Serotonin 2C Receptors Have increased Affective Responses to Aversive Stimuli.

Authors:  Stephen J Bonasera; A Katrin Schenk; Evan J Luxenberg; Xidao Wang; Allan Basbaum; Laurence H Tecott
Journal:  PLoS One       Date:  2015-12-02       Impact factor: 3.240
  7 in total

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