Effect of therapy time and frequency on effective solute removal.

Increasing dialysis frequency or time increases the removal of the molecules diffusing slowly across the intercompartmental barriers. By offering frequent dialysis the time on dialysis can be decreased, possibly without worsening the outcome. Increasing dialysis time increases large molecule removal. Increasing in both frequency and time on dialysis increases the removal of solutes of all molecular sizes. Increasing frequency and/or time of dialysis may have many other beneficial effects that are not traditionally quantitated and which can affect outcomes.