S N Ghaemi1, M S Lenox, R J Baldessarini. 1. Consolidated Department of Psychiatry, Harvard Medical School, Boston, Mass, USA. nassir_ghaemi@hms.harvard.edu
Abstract
OBJECTIVE: We sought to review research on use of antidepressants for long-term treatment of bipolar depression. METHOD: We conducted a computerized literature search of the MEDLINE, HealthStar, Current Contents, PsychInfo, and National Library of Medicine databases to identify studies involving antidepressant, anticonvulsant, or lithium use in bipolar disorder or manic-depressive illness published from 1966 through 2000. RESULTS: Only 7 blinded, controlled trials of long-term antidepressant treatment in bipolar disorders were found. The available information is not adequate to support the safety or effectiveness of long-term antidepressant treatment for bipolar depression, with or without mood-stabilizing cotherapy. CONCLUSION: Antidepressant treatment of bipolar depression is extraordinarily understudied. Controlled trials comparing specific antidepressants, particularly to compare mood-stabilizing agents given alone and combined with an antidepressant, are needed.
OBJECTIVE: We sought to review research on use of antidepressants for long-term treatment of bipolar depression. METHOD: We conducted a computerized literature search of the MEDLINE, HealthStar, Current Contents, PsychInfo, and National Library of Medicine databases to identify studies involving antidepressant, anticonvulsant, or lithium use in bipolar disorder or manic-depressive illness published from 1966 through 2000. RESULTS: Only 7 blinded, controlled trials of long-term antidepressant treatment in bipolar disorders were found. The available information is not adequate to support the safety or effectiveness of long-term antidepressant treatment for bipolar depression, with or without mood-stabilizing cotherapy. CONCLUSION: Antidepressant treatment of bipolar depression is extraordinarily understudied. Controlled trials comparing specific antidepressants, particularly to compare mood-stabilizing agents given alone and combined with an antidepressant, are needed.
Authors: Wenjing Zhang; Yuan Xiao; Huaiqiang Sun; L Rodrigo Patino; Maxwell J Tallman; Wade A Weber; Caleb M Adler; Christina Klein; Jeffrey R Strawn; Fabiano G Nery; Qiyong Gong; John A Sweeney; Su Lui; Melissa P DelBello Journal: Neuropsychopharmacology Date: 2018-06-18 Impact factor: 7.853
Authors: Benjamin G Shapero; Jonathan P Stange; Kim E Goldstein; Chelsea L Black; Ashleigh R Molz; Elissa J Hamlat; Shimrit K Black; Angelo S Boccia; Lyn Y Abramson; Lauren B Alloy Journal: Int J Cogn Ther Date: 2015-03