P Saviuc1, D Garon, V Danel, J M Richard. 1. Unité de toxicologie clinique, Département pluridisciplinaire de médecine, Centre hospitalier universitaire de Grenoble. Psaviuc@chu-grenoble.fr
Abstract
UNLABELLED: Cortinarius spp. poisoning is characterized by a delayed acute renal failure (ARF). The main features of this severe poisoning are still poorly known and often overlooked. The aim of this review of the literature was a better description of Cortinarius spp. poisoning. METHODS: The main medical databases were searched and analysed. RESULTS: 245 cases were collected and 90 cases could be analysed in details. Gastrointestinal disorders appeared a few days after the ingestion of the mushrooms (median: three days). The renal phase is delayed (median: 8.5 days). Hepatic failure and muscular lesions are highly questionable. Treatment is supportive in half of the cases, ARF progressed towards chronic renal failure, which progressed in 70% of the cases towards terminal renal failure. CONCLUSION: Cortinarius spp. poisoning is severe. Ingestion of Cortinarius species must be systematically suspected whenever tubulo-interstitial nephritis is diagnosed.
UNLABELLED: Cortinarius spp. poisoning is characterized by a delayed acute renal failure (ARF). The main features of this severe poisoning are still poorly known and often overlooked. The aim of this review of the literature was a better description of Cortinarius spp. poisoning. METHODS: The main medical databases were searched and analysed. RESULTS: 245 cases were collected and 90 cases could be analysed in details. Gastrointestinal disorders appeared a few days after the ingestion of the mushrooms (median: three days). The renal phase is delayed (median: 8.5 days). Hepatic failure and muscular lesions are highly questionable. Treatment is supportive in half of the cases, ARF progressed towards chronic renal failure, which progressed in 70% of the cases towards terminal renal failure. CONCLUSION: Cortinarius spp. poisoning is severe. Ingestion of Cortinarius species must be systematically suspected whenever tubulo-interstitial nephritis is diagnosed.