| Literature DB >> 11487016 |
S P Watson1, N Asazuma, B Atkinson, O Berlanga, D Best, R Bobe, G Jarvis, S Marshall, D Snell, M Stafford, D Tulasne, J Wilde, P Wonerow, J Frampton.
Abstract
The major activation-inducing collagen receptor glycoprotein VI (GPVI) has been cloned within the last two years. It is a member of the Ig superfamily of proteins and is constitutively associated with the ITAM-bearing Fc receptor gamma-chain (FcR gamma-chain). GPVI signals through a pathway that involves several of the proteins used by Fc, B- and T-lymphocyte receptors and which takes place in glycolipid-enriched membrane domains in the plasma membrane known as GEMs. Responses to GPVI are regulated by PECAM-1 (CD31) and possibly other ITIM-bearing receptors. Despite a pivotal role for GPVI, there are important differences between signalling events to collagen and GPVI-specific ligands. This may reflect a role for co-receptors in the response to collagen.Entities:
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Year: 2001 PMID： 11487016
Source DB: PubMed Journal: Thromb Haemost ISSN： 0340-6245 Impact factor: 5.249