| Literature DB >> 11485898 |
J A Bridge1, M Kanamori, Z Ma, D Pickering, D A Hill, W Lydiatt, M Y Lui, G W Colleoni, C R Antonescu, M Ladanyi, S W Morris.
Abstract
Inflammatory myofibroblastic tumor (IMT) is a rare, but distinctive mesenchymal neoplasm composed of fascicles of bland myofibroblasts admixed with a prominent inflammatory component. Genetic studies of IMTs have demonstrated chromosomal abnormalities of 2p23 and rearrangement of the anaplastic lymphoma kinase (ALK) gene locus. In a subset of IMTs, the ALK C-terminal kinase domain is fused with a tropomyosin N-terminal coiled-coil domain. In the current study, fusion of ALK with the clathrin heavy chain (CTLC) gene localized to 17q23 was detected in two cases of IMT. One of these cases exhibited a 2;17 translocation in addition to other karyotypic anomalies [46,XX,t(2;17)(p23;q23),add(16)(q24)].Entities:
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Year: 2001 PMID： 11485898 PMCID： PMC1850566 DOI： 10.1016/S0002-9440(10)61711-7
Source DB: PubMed Journal: Am J Pathol ISSN： 0002-9440 Impact factor: 4.307