| Literature DB >> 11485467 |
M O Rasmussen1, P Delair, A E Greene.
Abstract
A highly stereoselective approach to (-)-2-epilentiginosine and (+)-lentiginosine has been developed based on a diastereofacially selective cycloaddition of dichloroketene with a chiral dienol ether. The two naturally occurring indolizidines are each obtained enantioselectively (> or = 99:1) in ca. 8.5% overall yield.Entities:
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Year: 2001 PMID： 11485467 DOI： 10.1021/jo010298r
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354