Literature DB >> 11483731

Copper binding to the PrP isoforms: a putative marker of their conformation and function.

Y Shaked1, H Rosenmann, N Hijazi, M Halimi, R Gabizon.   

Abstract

We show here that PrP(C), the normal isoform of the prion protein (PrP(Sc)), could be retained by a Cu(2+)-loaded resin through two different binding sites. Contrarily, PrP(Sc) was not retained at all by such resin. This constitutes a new prion-specific property of PrP(Sc), which in addition to protease resistance and beta-sheet content, may result from its aberrant conformation.

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Year:  2001        PMID： 11483731      PMCID： PMC115030          DOI： 10.1128/jvi.75.17.7872-7874.2001

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  16 in total

1.  Scrapie prion rod formation in vitro requires both detergent extraction and limited proteolysis.

Authors:  M P McKinley; R K Meyer; L Kenaga; F Rahbar; R Cotter; A Serban; S B Prusiner
Journal:  J Virol       Date:  1991-03       Impact factor: 5.103

2.  Prion protein selectively binds copper(II) ions.

Authors:  J Stöckel; J Safar; A C Wallace; F E Cohen; S B Prusiner
Journal:  Biochemistry       Date:  1998-05-19       Impact factor: 3.162

3.  Contribution of a peroxide adduct of copper(II)-peptide complex to modify the secondary structure of albumin.

Authors:  Y Ishikawa; S Ito; S Nishino; S Ohba; Y Nishida
Journal:  Z Naturforsch C J Biosci       Date:  1998 May-Jun

4.  Characterization of detergent-insoluble complexes containing the cellular prion protein and its scrapie isoform.

Authors:  N Naslavsky; R Stein; A Yanai; G Friedlander; A Taraboulos
Journal:  J Biol Chem       Date:  1997-03-07       Impact factor: 5.157

5.  Characterization of prion proteins with monospecific antisera to synthetic peptides.

Authors:  R A Barry; M T Vincent; S B Kent; L E Hood; S B Prusiner
Journal:  J Immunol       Date:  1988-02-15       Impact factor: 5.422

6.  Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

Authors:  K M Pan; M Baldwin; J Nguyen; M Gasset; A Serban; D Groth; I Mehlhorn; Z Huang; R J Fletterick; F E Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  1993-12-01       Impact factor: 11.205

Review 7.  Prions.

Authors:  S B Prusiner
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-10       Impact factor: 11.205

8.  Purification and properties of the cellular prion protein from Syrian hamster brain.

Authors:  K M Pan; N Stahl; S B Prusiner
Journal:  Protein Sci       Date:  1992-10       Impact factor: 6.725

9.  Copper binding to the N-terminal tandem repeat regions of mammalian and avian prion protein.

Authors:  M P Hornshaw; J R McDermott; J M Candy
Journal:  Biochem Biophys Res Commun       Date:  1995-02-15       Impact factor: 3.575

10.  Cholesterol depletion and modification of COOH-terminal targeting sequence of the prion protein inhibit formation of the scrapie isoform.

Authors:  A Taraboulos; M Scott; A Semenov; D Avrahami; L Laszlo; S B Prusiner; D Avraham
Journal:  J Cell Biol       Date:  1995-04       Impact factor: 10.539
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  6 in total

1.  Proteolytic processing and glycosylation influence formation of porcine prion protein complexes.

Authors:  Krzysztof Nieznanski; Marcin Rutkowski; Magdalena Dominik; Dariusz Stepkowski
Journal:  Biochem J       Date:  2005-04-01       Impact factor: 3.857

2.  Nanoengineered analytical immobilized metal affinity chromatography stationary phase by atom transfer radical polymerization: separation of synthetic prion peptides.

Authors:  P McCarthy; M Chattopadhyay; G L Millhauser; N V Tsarevsky; L Bombalski; K Matyjaszewski; D Shimmin; N Avdalovic; C Pohl
Journal:  Anal Biochem       Date:  2007-03-13       Impact factor: 3.365

3.  Separation of native prion protein (PrP) glycoforms by copper-binding using immobilized metal affinity chromatography (IMAC).

Authors:  Henrik Müller; Alexander Strom; Gerhard Hunsmann; Andreas W Stuke
Journal:  Biochem J       Date:  2005-05-15       Impact factor: 3.857

4.  Flotillin-1 mediates PrPc endocytosis in the cultured cells during Cu²⁺ stimulation through molecular interaction.

Authors:  Ke Ren; Chen Gao; Jin Zhang; Ke Wang; Yin Xu; Shao-Bin Wang; Hui Wang; Chan Tian; Qi Shi; Xiao-Ping Dong
Journal:  Mol Neurobiol       Date:  2013-04-27       Impact factor: 5.590

5.  Endogenous proteolytic cleavage of disease-associated prion protein to produce C2 fragments is strongly cell- and tissue-dependent.

Authors:  Michel Dron; Mohammed Moudjou; Jérôme Chapuis; Muhammad Khalid Farooq Salamat; Julie Bernard; Sabrina Cronier; Christelle Langevin; Hubert Laude
Journal:  J Biol Chem       Date:  2010-02-12       Impact factor: 5.157

Review 6.  Structural Consequences of Copper Binding to the Prion Protein.

Authors:  Giulia Salzano; Gabriele Giachin; Giuseppe Legname
Journal:  Cells       Date:  2019-07-25       Impact factor: 6.600
  6 in total

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