| Literature DB >> 11482778 |
E M Galati1, M T Monforte, N Miceli, E Raneri.
Abstract
We studied in mice the neuropharmacological effect of some 5-substituted bromopyrazolinic spirobarbiturates. LD50 and CL50 values were estimated for all the investigated compounds. The effect on potentiation of sodium pentobarbital activity and on generalised tonic-clonic seizures produced by PTZ on mice was studied. All the compounds had the same pharmacological profile, they extended sleeping-time induced by sodium pentobarbital and showed protection against PTZ-induced convulsions, decreasing the death rate.Entities:
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Year: 2001 PMID： 11482778 DOI： 10.1016/s0014-827x(01)01062-x
Source DB: PubMed Journal: Farmaco ISSN： 0014-827X