Literature DB >> 11481456

Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.

Y Ruan1, L Tecott, M M Jiang, L Y Jan, Y N Jan.   

Abstract

Neurogenic genes in the Notch receptor-mediated signaling pathway play important roles in neuronal cell fate specification as well as neuronal differentiation. The Drosophila neuralized gene is one of the neurogenic genes. We have cloned a mouse homolog of Drosophila neuralized, m-neu1, and found that the m-neu1 transcript is expressed in differentiated neurons. Mice deficient for m-neu1 are viable and morphologically normal, but exhibit specific defects in olfactory discrimination and hypersensitivity to ethanol. These findings reveal an essential role of m-neu1 in ensuring proper processing of certain information in the adult brain.

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Year:  2001        PMID： 11481456      PMCID： PMC55551          DOI： 10.1073/pnas.171321098

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  36 in total

1.  Nuclear Notch1 signaling and the regulation of dendritic development.

Authors:  L Redmond; S R Oh; C Hicks; G Weinmaster; A Ghosh
Journal:  Nat Neurosci       Date:  2000-01       Impact factor: 24.884

Review 2.  Notch and presenilins in vertebrates and invertebrates: implications for neuronal development and degeneration.

Authors:  D J Selkoe
Journal:  Curr Opin Neurobiol       Date:  2000-02       Impact factor: 6.627

3.  Functional interactions of neurogenic genes of Drosophila melanogaster.

Authors:  A de-la-Concha; U Dietrich; D Weigel; J A Campos-Ortega
Journal:  Genetics       Date:  1988-03       Impact factor: 4.562

Review 4.  Neurogenic genes and vertebrate neurogenesis.

Authors:  J Lewis
Journal:  Curr Opin Neurobiol       Date:  1996-02       Impact factor: 6.627

Review 5.  The RING finger domain: a recent example of a sequence-structure family.

Authors:  K L Borden; P S Freemont
Journal:  Curr Opin Struct Biol       Date:  1996-06       Impact factor: 6.809

6.  Genomic sequencing.

Authors:  G M Church; W Gilbert
Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

7.  Place navigation impaired in rats with hippocampal lesions.

Authors:  R G Morris; P Garrud; J N Rawlins; J O'Keefe
Journal:  Nature       Date:  1982-06-24       Impact factor: 49.962

8.  Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome.

Authors:  C Ikonomidou; P Bittigau; M J Ishimaru; D F Wozniak; C Koch; K Genz; M T Price; V Stefovska; F Hörster; T Tenkova; K Dikranian; J W Olney
Journal:  Science       Date:  2000-02-11       Impact factor: 47.728

9.  Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

Authors:  A Nagy; J Rossant; R Nagy; W Abramow-Newerly; J C Roder
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-15       Impact factor: 11.205

10.  A single protocol to detect transcripts of various types and expression levels in neural tissue and cultured cells: in situ hybridization using digoxigenin-labelled cRNA probes.

Authors:  N Schaeren-Wiemers; A Gerfin-Moser
Journal:  Histochemistry       Date:  1993-12
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  17 in total

Review 1.  Canonical and non-canonical Notch ligands.

Authors:  Brendan D'Souza; Laurence Meloty-Kapella; Gerry Weinmaster
Journal:  Curr Top Dev Biol       Date:  2010       Impact factor: 4.897

2.  Information fluency for undergraduate biology majors: applications of inquiry-based learning in a developmental biology course.

Authors:  Kathleen M Gehring; Deborah A Eastman
Journal:  CBE Life Sci Educ       Date:  2008       Impact factor: 3.325

Review 3.  The many facets of Notch ligands.

Authors:  B D'Souza; A Miyamoto; G Weinmaster
Journal:  Oncogene       Date:  2008-09-01       Impact factor: 9.867

Review 4.  Notch ligand ubiquitylation: what is it good for?

Authors:  Gerry Weinmaster; Janice A Fischer
Journal:  Dev Cell       Date:  2011-07-19       Impact factor: 12.270

Review 5.  Notch and the skeleton.

Authors:  Stefano Zanotti; Ernesto Canalis
Journal:  Mol Cell Biol       Date:  2009-12-07       Impact factor: 4.272

6.  Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.

Authors:  Natalia Teider; Deborah K Scott; Adrianne Neiss; S Dilhan Weeraratne; Vladimir M Amani; Yifei Wang; Victor E Marquez; Yoon-Jae Cho; Scott L Pomeroy
Journal:  Neuro Oncol       Date:  2010-09-16       Impact factor: 12.300

7.  Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice.

Authors:  Hyun-Woo Jeong; Un Sil Jeon; Bon-Kyoung Koo; Wan-Young Kim; Sun-Kyoung Im; Juhee Shin; Yunje Cho; Jin Kim; Young-Yun Kong
Journal:  J Clin Invest       Date:  2009-10-12       Impact factor: 14.808

8.  Competing interactions between micro-RNAs determine neural progenitor survival and proliferation after ethanol exposure: evidence from an ex vivo model of the fetal cerebral cortical neuroepithelium.

Authors:  Pratheesh Sathyan; Honey B Golden; Rajesh C Miranda
Journal:  J Neurosci       Date:  2007-08-08       Impact factor: 6.167

9.  Mind bomb-1 in dendritic cells is specifically required for Notch-mediated T helper type 2 differentiation.

Authors:  Hyun-Woo Jeong; Ji-Hoon Kim; Joo-Yeon Kim; Sang-Jun Ha; Young-Yun Kong
Journal:  PLoS One       Date:  2012-04-27       Impact factor: 3.240

10.  The intracellular region of Notch ligands: does the tail make the difference?

Authors:  Alessandro Pintar; Alfredo De Biasio; Matija Popovic; Neli Ivanova; Sándor Pongor
Journal:  Biol Direct       Date:  2007-07-10       Impact factor: 4.540
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